Summary
Experimental brain lesions were created by Nd∶YAG laser (wave length 1.06 μm) irradiation on the cerebral cortex of anaesthesized adult cats with 20 Watts impacts of 0.5, 1.0, 2.5, and 5.0 seconds exposure time through cranial windows. Histological changes, disruption of the blood-brain barrier (Evans blue extravasation) and pial vessel reaction (large vessels more than 100 μm and vessels smaller than 100 μm) were studied under constant PaCO2, blood pH, and mean arterial pressure.
Histological changes of the lesions consisted of a zone of dense coagulation, a pale zone of homogeneous coagulation and an oedematous zone. Evans blue extravasation was uniformly seen extending from the histologically changed area into the surrounding tissue in all experiments. Pial arteries in the area with morphological changes showed pronounced dilatation (100.0±7.2%) and one third of these arteries were closed by thrombi. Pial arteries in the area of Evans blue extravasation but outside of histological changes also dilated (large arteries 60±4.1%, small arteries 77±5.9%). Pial arteries outside of the Evans blue extravasation were affected transiently and only in a very small zone: Within a distance of 200 μm from the Evans blue extravasation, large arteries initially dilated by 41±8.3%; small arteries dilated within 400 μm (42±3.7%). Within 4 minutes after irradiation arterial dilatation was again significantly reduced (p<0.01). It is concluded that no important vascular changes occur beyond the zones of histologically altered brain tissue.
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References
Ascher PW (1982) The use of CO2 in neurosurgery. In: Kaplan I (ed) Microscopic and endoscopic surgery with CO2 laser. John Wright-PSG, Boston Bristol London, pp 298–314
Auer LM, Haydn F (1979) Multichannel videoangiometry for continuous measurement of pial microvessels. Acta Neurol Scand 60 [Suppl 72] 208–209
Auer LM, Holzer P, Ascher PW, Heppner F (1988) Endoscopic neurosurgery. Acta Neurochir (Wien) 90: 1–14
Beck OJ, Wilske J, Schonberger JL (1979) Tissue changes following application of lasers to the rabbit brain. Neurosurg Rev 1: 31–36
Brown TE, True C, McLaurin RL (1966) Laser radiation. Acute effect on cerebral cortex. Neurology 16: 730–737
Eggert HR (1983) Grundlagen zur Anwendung des Nd-YAG-Lasers bei der Operation von intrakraniellen Tumoren. Habilitationsschrift. Albert Ludwigs Universität Freiburg
Fox JL (1969) The use of laser radiation as a surgical “light knife”. J Surg Res 9: 199–205
James HE, Schneider S, Bhasin S (1987) Experimental carbon dioxide laser brain lesions and intracranial dynamics: Part 3. Effect on cerebral blood flow. Neurosurgery 20: 219–221
Leheta F, Gorisch W (1976) Coagulation of blood vessels by means of argon ion and Nd-YAG-laser radiation. In: Kaplan I (ed) Laser surgery. Proceedings of the 1st International Symposium on Laser Surgery, Israel 1975. Academish Press, Jerusalem
Liss L, Roppel R (1966) Histopathology of laser-produced lesions in cat brains. Neurology 16: 783–790
Martiniuk R, Bauer JA, McKean JDS, Tulp J, Mielke BW (1989) New long-wavelength Nd∶YAG laser at 1.44 μm: effect on brain. J Neurosurg 70: 249–256
Stellar S, Polanyi TG, Bredemeier HC (1970) Experimental studies with carbon dioxide laser as a neurosurgical instrument. Med Biol Eng Compt 8: 549–558
Tiznado EG, James HE, Kemper C (1985) Experimental carbon dioxide laser brain lesions and intracranial dynamics: Part I. Effect on intracranial pressure, systemic arterial pressure, central venous pressure, electroencephalography and gross pathology. Neurosurgery 16: 5–8
Tiznado EG, James HE, Moore S (1985) Experimental carbon dioxide laser brain lesions and intracranial dynamics: Part 2. Effect on brain water content and its response to acute therapy. Neurosurgery 16: 454–457
Toya S, Kawase T, Iisaki Y, Owata T, Aki T, Nakamura T (1980) Acute effect of carbon dioxide laser on the epicerebral microcirculation. J Neurosurg 53: 193–197
Walter GF, Ascher PW, Ingolitsch E (1984) The effects of carbon dioxide- and neodymium-YAG lasers on the central and peripheral nervous systems, and cerebral blood vessels. J Neurol Neurosurg Psychiatry 47: 745–749
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Sakaki, T., Kleinert, R., Ascher, P.W. et al. Acute effect of neodymium yttrium aluminium garment laser on the cerebral cortical structure, blood-brain barrier, and pial vessel behaviour in the cat. Acta neurochir 109, 133–139 (1991). https://doi.org/10.1007/BF01403008
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DOI: https://doi.org/10.1007/BF01403008