Summary
Changes in blood-vessels, in configuration similar to arteriosclerosis, are found in malignant gliomas, especially in glioblastomas, as well as in metastases of carcinomas. Since analogous changes in vessel walls were not seen in primary tumours pertaining to cerebral metastases and in metastases of the body, this can obviously be considered as a phenomenon milieu-specific in nature. It is reasoned that this phenomenon can essentially be attributed to decomposition of medullary substance and influx of resulting disintegration products (lipids and cholesterol) into the vessel walls.
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References
Baker, A. B., The smaller incracerebral arteries. Neurology7 (1959), 391–396.
Bruetman, M. E., Litrenka, M. M., Saadia, J. M., Pathological studies on the distribution of arteriosclerotic lesions of the cerebral arteries. Trans. Amer. Neurol. Ass.94 (1969), 25–28.
Hagerstrand, I., Vascular changes in cerebral metastases. Acta pathol. microbiol. Scand.51 (1961), 63–71.
Hardman, J., Angioarchitecture of the gliomata. Brain63 (1940), 91–118.
Hsieh, H. H., Cerebrovascular disease: a comparative study of cerebral and visceral arteries. Neurology17 (1967), 752–762.
Lindgren, A., Röntgenologie einschlie\lich Kontrastmethoden. In: Handbuch der Neurochirurgie, Bd. II (Olivecrona, H., Tönnis, W., eds.). Berlin-Heidelberg: Springer. 1954.
Long, D. M., Capillary ultrastructure and blood-brain-barrier in human malignant brain tumors. J. Neurosurg.32 (1970), 127–144.
Müller, W., Pathologische Gefä\wandveränderungen im Neurinom und deren Ursache. Zbl. Neurochir.29 (1968), 91–95.
Murata, K., Teresawa, F., Hosoda, S., Ikeda, M., Seki, M., Relation of blood pressure and serum total cholesterol to severity of atherosclerotic lesions in aorta, coronary and cerebral arteries. Jap. Heart J.12 (1971), 460–466.
Nyström, S., Pathological changes in blood vessels of human glioblastoma multiforme. Acta pathol. microbiol. Scand.49 (Suppl. 137), (1960), 1–83.
Rath, I., Histologische Untersuchungen über den spezifischen Einflu\ des Hirngewebes auf das Bild der regressiven Gefä\veränderungen in den intrazerebralen malignen Tumoren. Inaug.-Diss. Univ. Köln. 1976.
Rothemund, E., Frische, M., Klinisch-pathologische Studien zur Entstehung der intracerebralen Gefä\hyalinose bei Hypertonie. Arch. Psychiat. Nervenkr.217 (1973), 195–206.
Scatliff, J. H., Vascular structure of glioblastomas. Amer. J. Roentgenol.105 (1969), 795–805.
Schiefer, W., Tönnis, W., Udvarhelyi, G., Das Glioblastoma multiforme im Serienangiogramm. Acta Neurochir. (Wien)4 (1954), 76–105.
Shimoda, A., Electronoptic studies on the perivascular structure of the brain with special reference to changes in cerebral edema and swelling. Dtsch. Z. Nervenheilk.183 (1961), 78–98.
Spielmeyer, W., Histopathologie des Nervensystems. Berlin: Springer. 1922.
Tönnis, W., Diagnostik der intrakraniellen Geschwülste. In: Handbuch der Neurochirurgie, Bd. IV/3, pp. 1–579 (Olivecrona, H., Tönnis, W., eds.). Berlin-Göttingen-Heidelberg: Springer. 1962.
Torack, R., Ultrastructure of capillary reaction to brain tumors. Arch. Neurol.5 (1961), 416–428.
Udvarhelyi, G., Walter, W., Schiefer, W., Gefä\struktur des Glioblastoma multiforme in angiographischer und histologischer Darstellung. Acta Neurochir. (Wien)4 (1955), 109–127.
Ueda, K., Pathological comparison of cerebral and coronary arteriosclerosis with special reference to the cases with vascular disorders of the brain and heart. Acta Med. (Fukuoka)40 (1970), 1–49.
Zollinger, H. U., Pathologische Anatomie. Stuttgart: Thieme. 1969.
Zülch, K. J., Biologie und Pathologie der Hirngeschwülste. In: Handbuch der Neurochirurgie, Bd. III., pp. 1–702 (Olivecrona, H., Tönnis, W., eds.). Berlin-Göttingen-Heidelberg: Springer. 1956.
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Rath, I., Müller, W. Milieu-specific vascular changes in malignant brain tumours. Acta neurochir 52, 203–208 (1980). https://doi.org/10.1007/BF01402075
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DOI: https://doi.org/10.1007/BF01402075