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Morphological Aspects of Tumor Angiogenesis

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Tumor Angiogenesis Assays

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1464))

Abstract

The tumor vasculature is a chaotic mixture of abnormal, hierarchically disorganized vessels that differ from those of normal tissues with respect to organization, structure and function. Firstly, tumor vessel wall structure is abnormal and heterogeneous within the tumor. Besides contractile wall components, the perivascular compartment is often lacking pericytes, what makes the tumor vessels fragile and leaky. Secondly, another group of abnormalities involves distortions in angioarchitecture and vasculature as network. Common features of tumor vessels, irrespective of their origin, size and growth pattern, are absence of hierarchical organization, formation of vessels with irregular contours and their heterogeneous distribution within the tumor.

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Authors and Affiliations

  1. Institute of Anatomy, University of Bern, Baltzerstrasse 2, 3000, Bern, Switzerland

    Ruslan Hlushchuk, Sébastien Barré & Valentin Djonov

Authors
  1. Ruslan Hlushchuk
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  2. Sébastien Barré
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  3. Valentin Djonov
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Correspondence to Ruslan Hlushchuk .

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Editors and Affiliations

  1. Neurosciences and Sensory Organs, University of Bari,School of Med Dept of Basic Med Sci, Bari, Italy

    Domenico Ribatti

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Hlushchuk, R., Barré, S., Djonov, V. (2016). Morphological Aspects of Tumor Angiogenesis. In: Ribatti, D. (eds) Tumor Angiogenesis Assays. Methods in Molecular Biology, vol 1464. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-3999-2_2

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  • DOI: https://doi.org/10.1007/978-1-4939-3999-2_2

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-3997-8

  • Online ISBN: 978-1-4939-3999-2

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