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Correlations of female steroid hormone receptors with histologic features in meningiomas

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Summary

A series of 39 samples were obtained from meningiomas in 28 patients in order to investigate the relationships of the oestrogen receptor (OER) and progesterone receptor (PR) with the tumoural subtype and some histological features. Twenty-one samples were positive (> 10 fmole/mg protein), 7 were OER-PR-negative, and 1 was positive in both receptors. Twenty-two samples were considered as syncitial, 7 transitional, 7 fibroblastic and 3 angioblastic. The histological subtype was not found to be significantly related to the presence or absence of PR. Relations were not observed between the progestin receptor and the following histological parametrs: cellular pattern, cell density, nuclear polymorphism, mitosis, lymphoplasmacellular infiltrates, degree of vascularization, psammoma bodies and interstitial fibrosis. Only the presence of intratumoural necrosis was significantly related with a low PR levels. However, progesterone binding activity was lower in tumours with numerous psammomas, fibroblastic cell pattern and interstitial fibrosis. The clinical and biological significance of these results is discussed.

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References

  1. Aranyi P, Naray A (1980) Effect of calcium on chick thymus glucorticoid receptors. J Steroid Biochem 12: 267–272

    PubMed  Google Scholar 

  2. Bellur SN, Chandra V, Anderson RJ (1983) Association of meningiomas with obesity. Ann Neurol 13: 346–347

    PubMed  Google Scholar 

  3. Bickerstaff ER, Small JM, Guest IA (1958) The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiatry 21: 89–91

    Google Scholar 

  4. Blaauw G, Blankenstein MA, Lamberts SWJ (1986) Sex steroid receptors in human meningiomas. Acta Neurochir (Wien) 79: 42–47

    Google Scholar 

  5. Blankenstein MA, Blaauw G, Lamberts SWJ, Mulder E (1983) Presence of progesterone receptors and absence of estrogen receptors in human intracranial meningiomas cytosols. Europ J Cancer Clin Oncol 19: 365–370

    PubMed  Google Scholar 

  6. Cahill DW, Bashirelahi N, Solomon LW, Dalton T, Salcman M, Ducker TB (1984) Estrogen and progesterone receptors in meningiomas. J Neurosurg 60: 985–993

    PubMed  Google Scholar 

  7. Doneil MW, Meyer GA, Donegan WL (1979) Estrogen-receptor protein in intracranial meningiomas. J Neurosurg 50: 499–502

    PubMed  Google Scholar 

  8. Geisinger KM, Marshall RB, Kute TE, Homesley HD (1986) Correlation of female sex steroid and ultrastructural differentiation in adenocarcinoma of the endometrium. Cancer 58: 1506–1517

    PubMed  Google Scholar 

  9. Grunberg SM, Daniels AM, Muensch H, Daniels JR, Bernstein L, Kortes V, Weiss MH (1987) Correlation of meningioma hormone receptor status with hormone sensitivity in a tumor stemcell assay. J Neurosurg 66: 405–408

    PubMed  Google Scholar 

  10. Hayward E, Whitwell H, Barnes D (1984) Steroid receptors in human meningioma. Clin Neuropharmaeol 7: 351–356

    Google Scholar 

  11. Jan M, Pleader G (1984) Les recepteurs hormonaux d'oestrogégnes et de progestérone dans les méningiomes. Resultats et reflexions á popos de 26 cas. Neurochir 30: 373–377

    Google Scholar 

  12. Kepes JJ (1982) Meningiomas. Biology, pathology and differential diagnosis. Masson Publishing USA. Inc, New York

    Google Scholar 

  13. Korenman DG, Dukes BA (1970) Specific estrogen binding by the cytoplasm of human carcinoma. J Clin Endocrinol Metab 30: 639–645

    PubMed  Google Scholar 

  14. Lesch KP, Gross S (1987) Estrogen receptor immunoreactivity in meningiomas. Comparison with the binding activity of estrogen, progesterone and androgen receptors. J Neurosurg 67: 237–244

    PubMed  Google Scholar 

  15. Lluch A (1985) Receptores de estrógeno y progesterona en el cancer de mama. Tesis Doctoral. Facultad de Medicina. Universidad de Valencia

  16. MacCarty KS Jr, Barton TK, Fetter BF, Creasman WT, MacCarty KS Sr (1979) Correlation of estrogen and progesterone receptors with histological differentiation in endometrial adenocarcinoma. Am J Pathol 96: 171–184

    PubMed  Google Scholar 

  17. Magdelenat H, Pertuiset BF, Poisson M, Martin PM, Philippon J, Pertuiset B, Buge A (1982) Progestin and oestrogen receptors in meningiomas biochemical characterization clinical and pathological correlations in 42 cases. Acta Neurochir (Wien) 64: 199–213

    Google Scholar 

  18. Markwalder TM, Zava DT, Goldhirsch A, Marwalder RV (1983) Estrogen and progesterone receptors in meningiomas in relation to clinical and pathological features. Surg Neurol 20: 42–47

    PubMed  Google Scholar 

  19. Markwalder TM, Markwalder RV, Zava DT (1984) Estrogen and progestin receptors in meningiomas: clinicopathological correlations. Clin Neuropharmacol 7: 368–374

    PubMed  Google Scholar 

  20. Maturza RL, Douglas CM, MacLaughlin D (1985) Estrogen and progestin binding by cytosolic and nuclear fractions of human meningiomas. J Neurosurg 62: 750–756

    PubMed  Google Scholar 

  21. Piquer J (1988) Meningiomas: Estudio correlativo. Consideraciones clinicas, morfolögicas, immunohistoqumiicas, citogenéticas y hormonales. Tesis Doctoral. Facultad de Medicina. Universidad de Valencia

  22. Poisson M, Magdelenat H, Foncini JF, Bleibel JM, Philippon J, Pertuiset B, Buge A (1980) Rècepteurs d'oestrogènes et de progestérone dans les méningiomes. Étude de 22 cas. Rev Neurol (Paris) 136: 193–203

    Google Scholar 

  23. Quest DW (1976) Meningiomas: An update. Neurosurgery 3: 219–225

    Google Scholar 

  24. Rausin A, Ybo W, Stenflo J (1970) Intracranial meningioma. A population study often years. Acta Neurol Scand 46: 102–110

    PubMed  Google Scholar 

  25. Scatchard G (1949) The attractions of proteins for small molecules and ions. Am NY Acad Sci 51: 660–672

    Google Scholar 

  26. Schnegg JF, Gomez F, Marchand-Beraud T, DeTribolet N (1981) Presence of sex steroid hormone receptors in meningioma tissue. Surg Neurol 15: 415–416

    PubMed  Google Scholar 

  27. Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies of other sites. Neurology (Minneap) 25: 705–712

    Google Scholar 

  28. Sherman MR, Pickering LA, Rollwagen FM, Miller LK (1978) Meroreceptors: proteolytic fragments of receptors containing the steroid binding sites. Fed Proc 37: 167–173

    PubMed  Google Scholar 

  29. Tilzer LL, Plapp FV, Evans JP, Stone D, Alward K (1982) Steroid receptor proteins in human meningiomas. Cancer 49: 633–636

    PubMed  Google Scholar 

  30. Vaquero J, Marcos ML, Martinez R, Bravo G (1983) Estrogen and progesterone-receptor proteins in intracranial tumours. Surg Neurol 19: 11–13

    PubMed  Google Scholar 

  31. Yu ZH, Wrange O, Haglund B, Granholm L, Gustafsson JA (1982) Estrogen and progestin receptors in intracranial meningiomas. J Steroid Biochem 16: 451–456

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery,Facultad de Medicina (Hospital Clinico), University of Valencia, Spain

    J. Piquer & J. L. Barcia Salorio

  2. Department of Pathology, Facultad de Medicina (Hospital Clinico), University of Valencia, Spain

    M. Cerda

  3. Department of Medicine, Facultad de Medicina (Hospital Clinico), University of Valencia, Spain

    A. Lluch & J. Garcia-Conde

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  1. J. Piquer
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  2. M. Cerda
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  3. A. Lluch
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  4. J. L. Barcia Salorio
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  5. J. Garcia-Conde
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Piquer, J., Cerda, M., Lluch, A. et al. Correlations of female steroid hormone receptors with histologic features in meningiomas. Acta neurochir 110, 38–43 (1991). https://doi.org/10.1007/BF01402046

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