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The effect of systemic human interferon-alpha administration to patients with glioblastoma multiforme

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Summary

This report presents the results of a phase I trial of the value of human leucocyte inferon-alpha in the treatment of glioblastoma. Twelve patients entered the trial. In one case we believe that the patient benefitted from the interferon treatment. CT scans of patients on interferon did not reveal the true extent of the tumorous tissue.

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References

  1. Tönnis, W., Walter, W., Das Glioblastoma multiforme (Bericht über 2611 Fälle). Acta neurochir. (Wien)6 (1959), 40–46.

    Google Scholar 

  2. Jelsma, R., Bucy, P. C., The treatment of glioblastoma multiforme of the brain. J. Neurosurg.27 (1967), 388–400.

    PubMed  Google Scholar 

  3. Cianfriglia, F., Pompili, A., Riccio, A., Grassi, A. X., CCNU-chemotherapy of hemispheric supratentorial glioblastoma multiforme. Cancer45 (1980), 1289–1299.

    PubMed  Google Scholar 

  4. Hendler, F. J., Hanlon, K., Hekmatpanah, J., Griem, M. L., Duda, E. E., Mulligan, B., Wollman, R. L., Treatment of grade III and IV astrocytomas with BCNU alone and in combination with VM-26 following surgery and radiation therapy. Cancer Treat. Rep.63 (1979), 1707–1711.

    PubMed  Google Scholar 

  5. Mellstedt, H., Ähre, A., Björkholm, M., Holm, G., Johansson, B., Strander, H., Interferon therapy in myelomatosis. Lancet1 (1979), 245–247.

    PubMed  Google Scholar 

  6. Gutterman, J. U., Blumenschein, G. R., Alexanian, R., Yap, H. Y., Buzdar, A. V., Cavanillas, F., Hortobagyi, G. N., Distefano, A., Hersh, E. M., Rasmussen, S. L., Harmon, M., Pestka, S., Leukocyte interferon induced tumor regression in human metastatic breast cancer, multiple myeloma and malignant lymphoma. Ann. Intern. Med.93 (1980), 399–406.

    PubMed  Google Scholar 

  7. Blomgren, H., Cantell, K, Johansson, B., Lagergren, C., Ringborg, U., Strander, H., Interferon therapy in Hodgkin's disease. Acta Med. Scand.199 (1976), 527–532.

    PubMed  Google Scholar 

  8. Merigan, T. C., Sikova, K., Breeden, J. H., Levy, R., Rosenberg, S. A., A tumor reducing effect of human leukocyte interferon in non-Hodgkin's lymphoma. New Engl. J. Med.299 (1978), 1449–1453.

    PubMed  Google Scholar 

  9. Hill, N., Loeb, E., Pardue, A. S., Dorn, G. L., Khan, A., Hill, J. M., Response of acute leukemia to leukocyte interferon. J. Clin. Hemat. Oncol.9 (1979), 137–149.

    Google Scholar 

  10. Einhorn, N., Cantell, K., Einhorn, S., Strander, H., Human leukocyte interferon therapy for advanced ovarian carcinoma. Am. J. Clin. Oncol.5 (1982), 167–172.

    PubMed  Google Scholar 

  11. Cantell, K., Hirvonen, S., Koistinen, V., Partial purification of human leukocyte interferon on a large scale. Methods in Enzymology78 (1981), 499–505.

    PubMed  Google Scholar 

  12. Strander, H., Cantell, K., Production of interferon by human leukocytes in vitro. Ann. Med. Exp. Fenn.44 (1966), 265–273.

    PubMed  Google Scholar 

  13. Zülch, K. J., Histological typing of tumors of the central nervous system. International histological classification of tumors No. 21. WHO, Geneva, 1979.

    Google Scholar 

  14. Kernohan, J. W., Sayre, G. P., Tumors of the central nervous system. Atlas of tumor pathology, Section X, Fascicles 35, qand 37. Washington: Armed Forces Institute of Pathology. 1952.

    Google Scholar 

  15. Strömblad, L. G., Brun, A., Nordström, C.-H., Salford, L., Sandberg, M., Intratumoral och generell interferonbehandling av astrocytom III–IV. Abstract from Läkaresällskapets Riksstämma 1981.

  16. Nagi, M., Araik, T., Kohno, S., Kohase, M., Interferon therapy for malignant brain tumors. In: The clinical potential of interferons (Kono, R., Vilček, J., eds.), pp. 257–272. Tokyo University Press. 1982.

  17. Nakamura, O., Takakura, K., Kobayashi, S., Effect on human interferonbeta in the treatment of malignant brain tumors. UCLA Symp. Molecular Cell Biol.24 (1982), 465–477.

    Google Scholar 

  18. Suddith, R. L., Kelley, P. J., Hutchinson, H. T., Murray, E. A., Haber, B., In vitro demonstration of an endothelial proliferation factor produced by neural cell lines. Science190 (1975), 682–684.

    PubMed  Google Scholar 

  19. Kelly, P. J., Suddith, R. L., Hutchinson, K., Werrbach, K., Haber, B., Endothelial growth factor present in tissue culture of CNS tumors. J. Neurosurg.44 (1976), 342–346.

    PubMed  Google Scholar 

  20. Folkman, J., Cotran, R., Relation of vascular proliferation of tumor growth. Int. Rev. Exp. Path.16 (1976), 207–248.

    PubMed  Google Scholar 

  21. Zetter, B. R., Migration of capillary endothelial cells is stimulated by tumor-derived factors. Nature285 (1980), 41–43.

    PubMed  Google Scholar 

  22. Brouty-Boyé, D., Zetter, B. R., Inhibition of cell motility by interferon. Science208 (1980), 516–518.

    PubMed  Google Scholar 

  23. Gresser, I., Antitumor effects of interferon. In: Cancer—a comprehensive treatise. Chemotherapy, Vol. 51, pp. 525–571. New York: Plenum Publ. Corp. 1977.

    Google Scholar 

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Boëthius, J., Blomgren, H., Collins, V.P. et al. The effect of systemic human interferon-alpha administration to patients with glioblastoma multiforme. Acta neurochir 68, 239–251 (1983). https://doi.org/10.1007/BF01401182

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