Abstract
The mechanism by which oxethazaine inhibits hydrochloric acid stimulation of pancreatic secretion and the endogenous release of secretin was studied in six dogs prepared with pancreatic and gastric fistulae. Oxethazaine reduced both pancreatic secretion and plasma secretin concentration evoked by duodenal acidification, and the degree of inhibition was proportional to its dose. This drug did not inhibit the pancreatic secretion stimulated by the exogenous secretin. From kinetic analyses, it seems that oxethazaine acted as noncompetitive inhibitor of hydrogen ion on the chemoreceptors of the secretinreleasing cells in the duodenal mucosa. This may result in a decrease of secretin release from these cells and consequently of pancreatic secretion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Schapiro H, Woodward ER: Inhibition of the secretin mechanism by local anesthetics. Am Surgeon 31:139–141, 1965
Slyback JB, Swena EM, Thomas JE, Smith LL: The pancreatic secretory response to topical anesthetic block of the small bowel. Surgery 61:591–595, 1967
Thomas JE: An improved cannula for gastric and intestinal fistulas. Proc Soc Exp Biol 46:260–261, 1941
Noda A, Toda Y, Hayakawa T: Determination of the concentration of bicarbonate ion in duodenal aspirate by means of an autotitrator. Jpn J Clin Pathol 20:217–220, 1972
Yanaihara N, Sato H, Kubota M: Radioimmunoassay for secretin usingNα-tyrosyl-secretin and [Tyr1] secretin. Endocrinol Jpn 23:87–90, 1976
Yanaihara N, Sakagami M, Sato H, Yamamoto K, Hashimoto T, Yanaihara C, Ito Z, Yamaguchi K, Abe K: Immunological aspects of secretin, substance P, and VIP. Gastroenterology 72:803–810, 1977
Dunn OJ: Basic statistics. New York, Wiley, 1967
Dixon M, Webb EC: Enzymes. New York, Academic, 1960
Bayliss WM, Staling EH: The mechanism of pancreatic secretion. J Physiol 28:325–353, 1902
Preshaw RM, Cooke AR, Grossman MI: Quantitative aspects of response of canine pancreas to duodenal acidification. Am J Physiol 210:629–634, 1966
Gilbert OB, Grossman MI: Release of cholecystokinin by acid (38562). Proc Soc Exp Biol 148:463–467, 1975
Thomas AM, Stanislaw J, Konturek SJ, Llanos OL, Rayford PL, Thompson JC: The effect of fat on secretin release. Ann Surg. 187:303–308, 1978
Lee KY, Tai HH, Chey WY: Plasma secretin and gastrin responses to a meat meal and duodenal acidification in dogs. Am J Physiol 230:784–789, 1976
Johnson LR, Schanbacher LM, Dudrick SJ, Copeland EM: Effect of long-term parenteral feeding on pancreatic secretion and serum secretin. Am J Physiol 233:524–529, 1977
Thomas JE, Swena EM: The effect of local anesthetics applied to the intestinal mucosa on the response of pancreas to intestinal stimuli. Fed Proc 22:664, 1963
Straus E: Radioimmunoassay of gastrointestinal hormones. Gastroenterology 74:141–152, 1978
Mason JC, Murphy RF, Henry RW, Buchanan KD: Starvation-induced changes in secretin-like immunoreactivity of human plasma. Biochim Biophys Acta 582:322–331, 1979
Preshaw RM: Integration of nervous and hormonal mechanism for external pancreatic secretion.In The Handbook of Physiology, Section 6, Alimentary Canal, Volume II Secretion. FC Charles (section ed). Baltimore, Williams and Wilkins, 1967, pp. 997–1005
Redford M, Schofield B: The effect of local anesthesia of the pyloric antral mucosa on acid inhibition of gastrin-mediated acid secretion. J Physiol 180:304–320, 1965
Grossman MI: Integration of neural and hormonal control of gastric secretion. Physiologist 6:349–357, 1963
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yamazaki, Y. Inhibitory mechanism of oxethazaine on release of endogenous secretin and pancreatic response in dogs. Digest Dis Sci 27, 821–827 (1982). https://doi.org/10.1007/BF01391376
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01391376