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Stimulation of renal amino acid reabsorption after treatment with triiodothyronine or dexamethasone in amino acid loaded rats

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Summary

In adult female anaestetized rats, the influence of triiodothyronine or dexamethasone on renal amino acid handling was investigated in leucine (20mg/100g b.wt.) or glutamine (45mg/100g b.wt.) loaded animals. Bolus injections of both amino acids were followed by temporary increase in fractional excretion of the administered amino acids as well of the endogenous amino acids which were not administered.

Under load conditions (leucine and glutamine), dexamethasone treatment (60 μg/100 g b.wt. for 3 days, i.p. once daily) was followed by a stimulation of renal amino acid reabsorption. The increase in fractional amino acid excretion after amino acid load was significantly lower than in untreated rats. The effect of triiodothyronine (20,μg/1008 b.wt. for 3 days, i.p. once daily) was different in leucine and glutamine loaded animals: after leucine bolus injection a comparable stimulatory effect as shown for dexamethasone could be demonstrated, but after glutamine administration the stimulatory action of T3 was masked. T3 even increases fractional amino acid excretion in glutamine loaded rats as a sign of enhanced “house-keeping” in the renal tubular cells. These results confirm previous findings and indicate different effects of both hormones on the renal handling of amino acids.

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  1. Institute of Pharmacology and Toxicology, Friedrich Schiller University, D-07740, Jena, Germany

    Ch. Fleck, M. Aurich & M. Schwertfeger

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  1. Ch. Fleck
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  2. M. Aurich
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  3. M. Schwertfeger
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Fleck, C., Aurich, M. & Schwertfeger, M. Stimulation of renal amino acid reabsorption after treatment with triiodothyronine or dexamethasone in amino acid loaded rats. Amino Acids 12, 265–279 (1997). https://doi.org/10.1007/BF01373007

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  • DOI: https://doi.org/10.1007/BF01373007

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