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Compatibility of Tat and Rev transactivators in the primate lentiviruses

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Summary

Primate immunodeficiency viruses carry a unique set of transacting regulator genes, which are essential for viral replication. The exchangeability of these Tat and Rev transactivators derived from viruses of the four major subgroups identified to date was assessed in transient transfection and infection assay systems. The human immunodeficiency virus type 1 (HIV-1), a major causative virus of human AIDS, efficiently activated the other viruses. In contrast, thetat andrev gene products of HIV-2, SIVAGM (virus of the African green monkey), and SIVMND (virus of the mandrill) did not fully transactivate the HIV-1. In particular, therev of HIV-1 was not substantially replaced by those of the other viruses. The result that HIV-1 is distinct from the other immunodeficiency viruses with respect to the compatibility of two transactivators gives a firm functional basis for the unique phylogenetic position of HIV-1.

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Authors and Affiliations

  1. Institute for Virus Research, Kyoto University, Kyoto, Japan

    H. Sakai, J. -i. Sakuragi, S. Sakuragi, M. Kawamura & A. Adachi

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  1. H. Sakai
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  2. J. -i. Sakuragi
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  3. S. Sakuragi
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  4. M. Kawamura
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  5. A. Adachi
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Sakai, H., Sakuragi, J.i., Sakuragi, S. et al. Compatibility of Tat and Rev transactivators in the primate lentiviruses. Archives of Virology 129, 1–10 (1993). https://doi.org/10.1007/BF01316880

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  • DOI: https://doi.org/10.1007/BF01316880

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