Summary
The radioprotective activity of interferon inducers (tilorone, Acranil, poly I:C and LPS) was investigated against acute X-ray irradiation and prolonged60Cogamma rays irradiation. The endogenous spleen colony formation test and percentage of surviving mice 30 days after irradiation were used as indicators. All interferon inducers investigated proved to have radioprotective activity.
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Allen, L. B., Eagle, N. C., Huffman, J. H., Shuman, D. A., Meyer, R. B., Sidwell, R. W.: Enhancement of interferon antiviral action in L-cells by cyclic nucleotides. Proc. Soc. exp. Biol. Med.146, 580–584 (1974).
Burger, M. M., Bombik, B. M., Breckenridge, B. Mc. L., Sheppard, J. R.: Growth control and cyclic alterations of cyclic AMP in the cell cycle. Nature (New Biol.)239, 161–163 (1972).
Cerottini, J. C., Brunner, K. T., Lindahl, P., Gresser, I.: Inhibitory effect of interferon preparations and inducers on the multiplication of transplanted allogeneic spleen cells and syngeneic bone marrow cells. Nature (New Biol.)242, 152–153 (1973).
Dahl, H.: Human interferon and cell growth inhibition. Acta path. microb. scand. Sect. B85, 54–60 (1977).
Finter, N. B.: Interferons and Interferon Inducers. In:Neuberger, A., Tatum, E. L. (eds.), Frontiers of Biology (North-Holland Research Monographs, Vol. 2), p. 598. New York: American Elsevier Publishing Co. 1973.
Fleming, W. A., McNeill, T. A., Killen, M.: The effect of an inhibiting factor (interferon) on thein vitro growth of granulocyte-macrophage colonies. Immunology23, 429–437 (1972).
Fuchsberger, N., Hajnická, V., Borecký, L.: Antiviral and cell-growth inhibitory activities of highly purified L-cell interferon. An analysis of quantitative disproportions. Acta virol.19, 59–66 (1975).
Fuse, A., Kuwata, T.: Effects of interferon on the human clonal cell line, RSa: inhibition of macromolecular synthesis. J. gen. Virol.33, 17–24 (1976).
Gaffney, E. V., Picciano, P. T., Grant, C. A.: Inhibition of growth and transformation of human cells by interferon. J. Nat. Cancer Inst.50, 871–878 (1973).
Gidáli, J., Fehér, I., Gallyas, A., Várterész, V.: Colonyforming cells in irradiated, partially shielded endotoxin-treated mice. Radiation Res.39, 305–316 (1969).
Gláz, E. T., Szolgay, E., Stöger, I., Tálas, M.: Antiviral activity and induction of interferon-like substance by Quinacrine and Acranil. Antimicr. Ag. Chemother.3, 537–541 (1973).
Gresser, I.: Antitumor effects of interferon. Advances Cancer Res.16, 97–140 (1972).
Haitovich, A. G., Lvovsky, A. E.: The dynamics of production and some properties of interferon-like inhibitors former under the influence of AET and cystaphosin vivo and in cell cultures. Vopr. Virusol. (Moscow)20, 183–186 (1975).
Haitovich, A. G., Lvovsky, E. A., Kiseliov, P. N.: Radioprotective action of exogenous interferon. Radiobiologia (Moscow)14, 356–358 (1974).
Johnson, H. M.: Cyclic AMP regulation of mitogen-induced interferon production and mitogen suppression of immune response. Nature265, 154–155 (1977).
Lindhal-Magnusson, P., Leary, P., Gresser, I.: Interferon inhibits DNA synthesis induced in mouse lymphocytes by phytohemagglutinin or by allogenic cells. Nature (New Biol.)237, 120–121 (1972).
Lvovsky, A. E., Levy, H. B., Doherty, D. G., Baron, S.: Interferon induction by radioprotective mercaptoalkylamines and derived thiophosphates. Infect. Immun.15, 191–196 (1977).
Mayer, G. D., Krueger, R. F.: Tilorone hydrochloride: mode of action. Science169, 1214–1215 (1970).
McCulloch, E. A., Thompson, M. W., Siminovitch, L., Till, J. E.: Effect of bacterial endotoxin and haemopoietic colonyforming cells in the spleens of normal mice and mice of genotype S1/S1d. Cell Tissue Kinet.3, 47–54 (1970).
Mécs, J.: Regulation of interferon productionin vitro andin vivo by influencing the adenylate cyclase system. Acta microbiol. Acad. Sci. hung.20, 42 (1973).
Ohwaki, M., Kawade, Y.: Inhibition of multiplication of mouse cells in culture by interferon preparations. Acta virol.16, 477–486 (1972).
O'Shaugnessy, M. V., Lee, S. H. S., Rozee, K. R.: Interferon inhibition of DNA synthesis and cell division. Canad. J. Microbiol.18, 145–151 (1972).
Pacheco, D., Falcoff, R., Catinot, L., Floch, F., Werner, G. H., Falcoff, E.: Inhibitory effect of interferon on DNA and RNA synthesis in murine spleen cells stimulated by lectins. Ann. Immunol. (Inst. Pasteur)127 C, 163–171 (1976).
Paucker, K., Cantell, K., Henle, W.: Quantitative studies on viral interference in suspended L cells. III. Effect of interfering viruses and interferon on the growth rate of cells. Virology17, 324–334 (1962).
Reizin, F. N., Roikhel, V. M., Chumakov, M. P.: The influence of substances changing the intracellular concentration of cyclic adenosine 3′5′-monophosphate on interferon synthesis in chick embryo cell culture. Arch. Virol.49, 307–315 (1975).
Semina, O. V., Konoplyannikov, A. G., Poverenny, A. M.: Action of some biologically active preparations on a population of cells of stem haemopoietic fraction and on the survival of irradiated mice. I. Poly I: C. Radiobiologia (Moscow)14, 686–689 (1974).
Semina, O. V., Neifakh, Ju. A., Soboleva, E. L., Konoplyannikov, A. G., Poverenny, A. M.: Action of some biologically active preparations on a population of cells of stem haemopoietic fraction and on the survival of irradiated mice. III. Interferon. Radiobiologia (Moscow)16, 218–221 (1976).
Sinclair, W. K.: Cyclic X-ray responses in mammalian cellsin vitro. Radiation Res.33, 620–643 (1968).
Stewart, W. E., II., Gresser, I., Tovey, M. G., Bandu, M. Th., le Goff, S.: Identification of the cell multiplication inhibitory factors in interferon preparations as interferons. Nature262, 300–302 (1976).
Stöger, I., Szolgay, E., Tálas, M.: Interferon inducers as possible protectors of the haemopoietic system in proton and X-irradiated mice. In: Interferon and Interferon Inducers, 195–203 (Proceedings of the 3rd Regional Conference on Interferon and Interferon Inducers, Tihany, Hungary, Sept. 1974). Microb. Res. Group of the Hung. Acad. Sci. Budapest, 1975.
Tálas, M., Savchenko, N. Ja., Shein, V. I., Fedorenko, B. S., Ryzhov, N. I., Konstantinova, I. V.: Influence of interferon inductors on the progress of radiation disease in mice irradiated with high energy protons. Radiobiologia (Moscow)14, 237–241 (1974).
Tálas, M., Szolgay, E., Várterész, V., Koczkás, G.: Influence of acute and fractional X-irradiation on induction of interferonin vivo. Arch. ges. Virusforsch.38, 143–148 (1972).
Till, J. E., McCulloch, E. A.: Early repair processes in marrow cells irradiated and proliferatingin vivo. Radiation Res.18, 96–105 (1963).
Toley, M., Brouty-Boyé, D., Gresser, I.: Early effect of interferon on mouse leukemia cells cultivated in a chemostat. Proc. Nat. Acad. Sci. (U.S.A.)72, 2265 to 2269 (1975).
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Tálas, M., Szolgay, E. Radioprotective activity of interferon inducers. Archives of Virology 56, 309–315 (1978). https://doi.org/10.1007/BF01315281
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DOI: https://doi.org/10.1007/BF01315281