We showed that injection of IL-1β (Betaleukin) in a dose of 3 μg/kg 22 h before prolonged (21 h) exposure to low-intensity (10 mGy/min) γ-radiation in a dose of 12.6 Gy reduced the number of double-strand DNA breaks in murine spleen cells to the control level in 4 months after exposure and the number of double-strand DNA breaks induced by additional acute irradiation in a dose of 6 Gy. The results suggest that IL-1β can improve the efficiency of systems reducing the number of double-strand DNA breaks in murine spleen cells at delayed terms after exposure to prolonged low-intensity radiation.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 160, No. 10, pp. 474–477, October, 2015
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Vorobyeva, N.Y., Grekhova, A.K., Trubitsina, K.Y. et al. Interleukin-1β Can Reduce Manifestations of Delayed Effects of Prolonged Exposure to Low-Intensity γ-Radiation. Bull Exp Biol Med 160, 470–473 (2016). https://doi.org/10.1007/s10517-016-3199-3
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DOI: https://doi.org/10.1007/s10517-016-3199-3