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Endocytic transit inDictyostelium discoideum

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Summary

The cells ofDictyostelium discoideum are soil amoebae with a simple endocytic pathway: Particles or fluid are taken up at the plasma membrane in a process dependent on the actin cytoskeleton. After rapid acidification and subsequent neutralisation of the food vacuoles during which breakdown of the contents occurs, indigestible remnants are exocytosed. This tight coupling between endocytosis and exocytosis is thought to maintain membrane homeostasis. In spite of the apparent overall difference between the endocytic pathways of mammalian cells andD. discoideum, conserved proteins are involved in individual steps of endocytic transport, possibly indicating that in mammalian cells it is only the routing of marker that has evolved from a simple transit to a complex, branched pathway.

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  1. M. Maniak

    Present address: Abteilung Zellbiologie, Universität Gesamthochschule Kassel, Heinrich-Plett-Strasse 40, D-34132, Kassel, Germany

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  1. MRC Laboratory for Molecular Cell Biology, University College London, London

    M. Maniak

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Maniak, M. Endocytic transit inDictyostelium discoideum . Protoplasma 210, 25–30 (1999). https://doi.org/10.1007/BF01314951

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