Summary
After covalent attachment of bacterial lipopolysaccharide to the nucleoprotein of influenza A virus, this water-soluble antigen could be incorporated firmly into ISCOM. This potent “immunostimulating complex” induced the production of high antibody titers in mice and could partially protect the animals from a lethal challenge infection. After immunization with ISCOM preparations NP-specific cytotoxic T cell activity could not be demonstrated.
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Weiß, H.P., Stitz, L. & Becht, H. Immunogenic properties of ISCOM prepared with influenza virus nucleoprotein. Archives of Virology 114, 109–120 (1990). https://doi.org/10.1007/BF01311015
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DOI: https://doi.org/10.1007/BF01311015