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The DNA-binding properties of immediate-early and early proteins of murine cytomegalovirus

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Summary

The DNA-binding properties of the immediate early (IE) and early proteins induced by the murine cytomegalovirus (Smith strain) in permissively infected 3 T 3-L 1 cells and nonpermissively infected J 774 A.1 cells were characterized. Eight of 10 IE proteins and 4 of 7 early proteins had affinity for DNA (native or denatured). A 96 K IE protein was observed to have affinity for denatured DNA-cellulose when synthesized in J 774 A.1 cells but not when synthesized 3 T 3-L 1 cells.

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Author notes

  1. D. G. Walker

    Present address: Kinsmen Laboratory of Neurological Research, Department of Psychiatry, University of British Columbia, Vancouver, B.C., Canada

Authors and Affiliations

  1. Division of Medical Microbiology, University of British Columbia, Vancouver, British Columbia, Canada

    D. G. Walker & J. B. Hudson

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  1. D. G. Walker
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  2. J. B. Hudson
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Walker, D.G., Hudson, J.B. The DNA-binding properties of immediate-early and early proteins of murine cytomegalovirus. Archives of Virology 102, 233–243 (1988). https://doi.org/10.1007/BF01310828

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  • DOI: https://doi.org/10.1007/BF01310828

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