Abstract
We have measured gastrin, cholecystokinin (CCK), and pancreatic polypeptide (PP) release after a meal in normal dogs under basal conditions and during atropine infusion, and after various neural sections. Denervation of the gastric antrum (antral vagotomy) abolished the early part of the gastrin response to food. Truncal vagotomy, celiac ganglionectomy, and atropine reduced the early release of CCK, which occurred before the start of gastric emptying, suggesting that a neural, cholinergic mechanism may release CCK immediately after a meal. PP release was abolished by truncal vagotomy, and also by antral vagotomy. As no direct pathways are known between the antrum and the pancreas, this suggests either that antral afferents are essential for this response or that vagally mediated hormone release from the antrum mediates PP release.
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Dockray GJ, Tracy HJ: Atropine does not abolish cephalic vagal stimulation of gastrin release in dogs. J Physiol 306:473–480, 1980
Schwartz TW, Holst JJ, Fahrenkrug S, Lindkaer-Jensen S, Nielsen OV, Rehfeld JF, Shaffalitsky de Muckadell OB, Stadil F: Vagal cholinergic regulation of pancreatic polypeptide secretion. J Clin Invest 61:781–789, 1978
Taylor IL, Impicciatore M, Carter DC, Walsh JH: Effect of atropine and vagotomy on pancreatic polypeptide response to a meal in dogs. Am J Physiol 235:E443-e447, 1978
Wang CC, Grossman MI: Physiological determination of release of secretin and pancreozymin from intestine with transplanted pancreas. Am J Physiol 164:527–545, 1951
Chayvialle JA, Descos F, Bernard C, Martin A, Barbe C, Partensky C: Somatostatin in mucosa of stomach and duodenum in gastroduodenal disease. Gastroenterology 75: 13–19, 1978
Fourmy D, Pradeyrol L, Antoniotti H, Esteve J-P, Ribet A: Purification of radioiodinated cholecystokinin peptides by reverse phase HPLC. J Liq Chromatogr 5:757–776, 1982
Lilja P, Weiner I, Inoue K, Fried G, Greeley GH, Thompson JC: Release of cholecystokinin in response to food and intraduodenal fat in pigs, dogs and man. Surg Gynecol Obstet 159:557–561, 1984
Modlin M, Hansky J, Singer M, Walsh JH: Evidence that the cholinergic enteropancreatic reflex may be independent of cholecystokinin release. Surgery 86:352–361, 1979
Jacobs F, Akkermans LMA, Oei HY, Hoekstra A, Wittebol P.In Motility of the Digestive Tract. M Weibeck (ed). New York, Raven Press, pp 233–240, 1982
Hopman WPM, Jansen JBMJ, Lamers CBHW: Effect of atropine on the plasma cholecystokinin response to intraduodenal fat in man. Digestion 29:19–25, 1984
Konturek SJ, Radecki T, Thor P, Dembinski A: Release of cholecystokinin by amino acids. Proc Soc Exp Biol Med 143:305–309, 1973
Konturek SJ, Tasler J, Obtulowicz W: Effect of atropine on pancreatic responses to endogenous and exogenous cholecystokinin. Am J Dig Dis 17:911–917, 1972
Ertan A, Brooks FP, Arvan D, Williams ND: Mechanism of release of endogenous cholecystokinin by jejunal amino acid perfusion in man. Am J Dig Dis 20:813–823, 1975
Solomon TE, Grossman MI: Effects of atropine and vagotomy on response of transplanted pancreas. Am J Physiol 236:E186-E190, 1979
Singer MV, Solomon TE, Grossman MI: Effect of atropine on secretion from intact and transplanted pancreas in dog. Am J Physiol 238:G18-G22, 1980
Guzman S, Chayvialle J-A, Banks WA, Rayford PL, Thompson JC: Effect of vagal stimulation on pancreatic secretion and on blood levels of gastrin, cholecystokinin, secretin, vasoactive intestinal peptide and somatostatin. Surgery 86:329–336, 1979
Tiscornia OM, Martinez JL, Sarles H: some aspects of human and canine macroscopic pancreas innervation. Am J Gastroenterol 66:353–361, 1976
Lamy J, Sarles H, Michotey G, Richelme H, Payan H, Gastaud G, Sarles J-C: Oddite expérimentale chez le chien par irritation chronique du nerf splanchnique droit. Étude manometrique, radiologique et anatomique. Rev Franc Étud Clin Biol 11:611–615, 1966
Wolffe MM, McGuigan JE: Immunochemical characterisation of gastrinlike and cholecystokininlike peptides released in dogs in response to a peptone meal. Gastroenterology 87:323–334, 1984
Tiscornia OM: The neural control of exocrine and endocrine pancreas. Am J Gastroenterol 67:541–560, 1977
Taylor IL, Kauffman GL, Walsh JH, Trout H, Chew P, Harmon JW: Role of the small intestine and gastric antrum in pancreatic polypeptide release. Am J Physiol 240:G387-G391, 1981
Poulsen J, Delikaris P, Lovgreen NA, Schwartz TW: Impaired pancreatic innervation after pyloric transsection in dogs. Scand J Gastroenterol 18:17–22, 1983
Jonung M, Jonung T, Chen MH, Murphy RF, Joffe SN: Effect of extragastric vagotomy on pancreatic polypeptide in dogs. Digestion 29:103–106, 1984
Prinz RA, Sabbagh HE, Adrian TE, et al: Neural regulation of pancreatic polypeptide release. Surgery 94:1011–1018, 1983
Regan PT, Go VLW, Di Magno EP: Comparison of the effects of cholecystokinin octapeptide and cholecystokinin on pancreatic secretion, galbladder contraction and plasma pancreatic polypeptide in man. J Lab Clin Med 96:743–748, 1980
Guzman S, Lonovics J, Devitt PG, Hejtmancik KE, Rayford PL, Thompson JC: Hormone-stimulated release of pancreatic polypeptide before and after vagotomy in dogs. Am J Physiol 240:G114-G121, 1981
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This work has been presented in part at meetings of the Surgical Research Society (July 1984) and the British Society of Gastroenterology (September 1984).
C. D. Johnson was in receipt of a MRC/INSERM French Exchange Travelling Fellowship.
This work was supported by a grant from MRT No. 82. L. 0030.
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Johnson, C.D., Chayvialle, J.A., Devaux, M.A. et al. Neural pathways for the release of gastrin, cholecystokinin, and pancreatic polypeptide after a meal in dogs. Digest Dis Sci 31, 1361–1369 (1986). https://doi.org/10.1007/BF01299815
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DOI: https://doi.org/10.1007/BF01299815