Summary
A case of chronic intestinal pseudoobstruction secondary to systemic amyloidosis in a patient with multiple myeloma is described. Gastrointestinal symptoms and indices of nutrition improved markedly after commencing treatment with cisapride, which may have been responsible for relatively prolonged survival compared with similar reported cases.
Similar content being viewed by others
References
Kyle RA, Greipp PR: Amyloidosis: clinical and laboratory features in 229 cases. Mayo Clin Proc 58:665–683, 1983
Gilat T, Spiro HM: Amyloidosis and the gut. Am J Dig Dis 13:619–633, 1968
O'Doherty DP, Neoptolemos JP, Wood KF: Place of surgery in the management of amyloid disease. Br J Surg 74:83–88, 1987
Griffel B, Man B, Kraus L: Selective massive amyloidosis of small intestine. Arch Surg 110:215–217, 1975
Legge DA, Wollaeger EE, Carlson HC: Intestinal pseudoobstruction in systemic amyloidosis. Gut 11:764–767, 1970
Stanghellini V, Camilleri M, Malagelada J-R: Chronic idiopathic intestinal pseudo-obstruction: Clinical and intestinal manometric findings. Gut 28:5–12, 1987
Battle WM, Rubin MR, Cohen S, Snape WJ: Gastrointestinal motility dysfunction in amyloidosis. N Engl J Med 301:24–25, 1979
Carlson HC, Breen JF: Amyloidosis and plasma cell dyscrasias: gastrointestinal involvement. Semin Roentgenol 21:128–138, 1986
Edwards CA, Holden S, Brown C, Read NW: Effect of cisapride on the gastrointestinal transit of a solid meal in normal human subjects. Gut 28:13–16, 1987
Camilleri M, Brown AR, Zinsmeister AR, Malagelada JR: Cisapride corrects the impaired small bowel transit of chyme in chronic intestinal pseudo-obstruction. Gastroenterology 88:1340, 1985 (abstract)
Colemont LJ, Camilleri M: Chronic intestinal pseudoobstruction: Diagnosis and treatment. Mayo Clin Proc 64:60–70, 1989
Camilleri M, Malagelada J-R, Abell TL, Brown ML, Hench V, Zinsmeister AR: Effect of six weeks of treatment with cisapride in gastroparesis and intestinal pseudo-obstruction. Gastroenterology 96:704–12, 1989
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Fraser, A.G., Arthur, J.F. & Hamilton, I. Intestinal pseudoobstruction secondary to amyloidosis responsive to cisapride. Digest Dis Sci 36, 532–535 (1991). https://doi.org/10.1007/BF01298889
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01298889