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3. Ursachen und Therapie von Organversagen: Mediatoren, ihr Stellenwert und therapeutische Implikationen am Beispiel des septischen Patienten

Mediators in sepsis: Pathogenetic role and therapeutical implications

  • B. Wissenschaftliches Programm
  • I. Hauptthemen A. Chirurgische Intensivmedizin — Ursachen und Therapie von Organversagen
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Summary

Mediators from the coagulation system, the complement system, the kallikrein-kinin system and the arachidonic acid metabolism are made responsible for the pathogenesis of organ failure (ARDS) following sepsis. Products from these systems influence, directly or indirectly, vascular tone and permeability, especially in the pulmonary circulation. Besides these mediators, toxic oxygen species and proteases released from activated granulocytes and macrophages injure endothelial cells and provoke vascular leakage.

Zusammenfassung

Für die Entwicklung von Organkomplikationen im Rahmen einer Sepsis werden Mediatoren aus dem Gerinnungs-, dem Komplement-, dem Kallikrein-Kinin-System und aus dem Arachidonsäure-Metabolismus verantwortlich gemacht. Produkte aus diesen Systemen beeinflussen teils direkt, teils indirekt über Zielzellen, den Gefässtonus und die Gefässpermeabilität vor allem in der Lungenstrombahn. Neben diesen Mediatoren wirken insbesondere die aus aktivierten Granulocyten und Makrophagen liberierten toxischen Sauerstoffprodukte und Proteasen endothelschädigend und permeabilitätssteigernd.

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  1. Funktionsbereich Klinische Pathophysiologie und Experimentelle Medizin am Zentrum Innere Medizin der Justus Liebig-Universität, Klinikstrasse 36, D-6300, Giessen

    H. Neuhof

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Neuhof, H. 3. Ursachen und Therapie von Organversagen: Mediatoren, ihr Stellenwert und therapeutische Implikationen am Beispiel des septischen Patienten. Langenbecks Arch Chiv 372, 43–47 (1987). https://doi.org/10.1007/BF01297787

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  • DOI: https://doi.org/10.1007/BF01297787

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