Abstract
Total creatine kinase and its isoenzymes CK-MB and CK-BB were measured in the serum of patients admitted with acute abdominal pain or signs suggestive of an intraabdominal catastrophe. Total creatine kinase was measured by automated spectrophotometry, CK-MB by chemiluminescent assay, and CK-BB by radioimmunoassay. Patients were grouped according to their final diagnosis: intestinal infarction (N=8); all other diagnoses (N=22); controls (N=20). CK-BB in the infarction group (22.3±5.3 ng/ml, mean±se) was significantly greater (P<0.01) than in the noninfarction or the control groups (11.0±0.8 ng/ml and 5.8±0.7 ng/ml, respectively). There were no differences in total creatine kinase and CK-MB in the three groups. Stepwise deletion multiple regression analysis of 26 independent regressors showed that among a cluster of six significant variables (R 2=0.92,P<0.005), CK-BB>20 ng/ml was the best predictor of intestinal infarction. Results of this study indicate that CK-BB isoenzyme measurement may be useful in the diagnosis of intestinal infarction in man.
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Fried, M.W., Murthy, U.K., Hassig, S.R. et al. Creatine kinase isoenzymes in the diagnosis of intestinal infarction. Digest Dis Sci 36, 1589–1593 (1991). https://doi.org/10.1007/BF01296402
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DOI: https://doi.org/10.1007/BF01296402