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Effect of synthetic porcine neuropeptide Y (NPY) on splanchnic blood flows and Exocrine pancreatic secretion in dogs

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Abstract

This study examined the effect of synthetic porcine neuropeptide Y on the splanchnic blood flows and the exocrine pancreatic secretion in dogs. Graded doses of neuropeptide Y (0.1–5 μg/kg, intravenous) caused dose-dependent reduction of the secretin-stimulated exocrine pancreatic secretion and of the blood flows in the superior mesenteric artery, the portal vein, and the pancreatic tissue. Neuropeptide Y at 5 μg/kg reduced the blood flows to 45.9±13.3% (superior mesenteric artery), 63.0±10.5% (portal vein), and 77.9±4.8% (pancreatic tissue), respectively. This dose also reduced secretin-stimulated pancreatic juice volume and CCK-8 plus secretin-stimulated protein output to 65.2±9.3 and 63.3±14.0%, respectively. This study shows a potent vasoconstrictor effect of neuropeptide Y on splanchnic vessels. Neuropeptide Y also inhibited exocrine pancreatic secretion in a significant correlation with the reduction in pancreatic tissue blood flow, which suggests that reduction in the blood flow may be one of the possible mechanisms of the inhibitory action of neuropeptide Y on exocrine secretion.

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Authors and Affiliations

  1. First Department of Surgery, Faculty of Medicine, Kyoto University, Shogoin-kawara-cho 54, Sakyo-ku, 606, Kyoto, Japan

    Shoichiro Sumi MD,  Kazutomo Inoue MD, Masafumi Kogire MD, Ryuichiro Doi MD, Mitsutoshi Yun MD, Hiromu Kaji MD, Ryo Hosotani MD, Masaki Fujimura MD, Kotaro Uchida MD, Shinya Kiyama PhD, Kouki Kitagawa PhD, Haruaki Yajima PhD, Nobutaka Fujii PhD & Takayoshi Tobe MD

  2. Second Department of Surgery, Shiga Medical College, Shiga, Japan

    Shoichiro Sumi MD,  Kazutomo Inoue MD, Masafumi Kogire MD, Ryuichiro Doi MD, Mitsutoshi Yun MD, Hiromu Kaji MD, Ryo Hosotani MD, Masaki Fujimura MD, Kotaro Uchida MD, Shinya Kiyama PhD, Kouki Kitagawa PhD, Haruaki Yajima PhD, Nobutaka Fujii PhD & Takayoshi Tobe MD

  3. College of Medical Technology, Kyoto University, Kyoto, Japan

    Shoichiro Sumi MD,  Kazutomo Inoue MD, Masafumi Kogire MD, Ryuichiro Doi MD, Mitsutoshi Yun MD, Hiromu Kaji MD, Ryo Hosotani MD, Masaki Fujimura MD, Kotaro Uchida MD, Shinya Kiyama PhD, Kouki Kitagawa PhD, Haruaki Yajima PhD, Nobutaka Fujii PhD & Takayoshi Tobe MD

  4. Faculty of Pharmaceutical Sciences, Tokushima University, Tokushima, Japan

    Shoichiro Sumi MD,  Kazutomo Inoue MD, Masafumi Kogire MD, Ryuichiro Doi MD, Mitsutoshi Yun MD, Hiromu Kaji MD, Ryo Hosotani MD, Masaki Fujimura MD, Kotaro Uchida MD, Shinya Kiyama PhD, Kouki Kitagawa PhD, Haruaki Yajima PhD, Nobutaka Fujii PhD & Takayoshi Tobe MD

  5. Faculty of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan

    Shoichiro Sumi MD,  Kazutomo Inoue MD, Masafumi Kogire MD, Ryuichiro Doi MD, Mitsutoshi Yun MD, Hiromu Kaji MD, Ryo Hosotani MD, Masaki Fujimura MD, Kotaro Uchida MD, Shinya Kiyama PhD, Kouki Kitagawa PhD, Haruaki Yajima PhD, Nobutaka Fujii PhD & Takayoshi Tobe MD

Authors
  1. Shoichiro Sumi MD
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  2. Kazutomo Inoue MD
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  3. Masafumi Kogire MD
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  4. Ryuichiro Doi MD
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  5. Mitsutoshi Yun MD
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  7. Ryo Hosotani MD
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  8. Masaki Fujimura MD
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  10. Shinya Kiyama PhD
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  11. Kouki Kitagawa PhD
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  12. Haruaki Yajima PhD
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  13. Nobutaka Fujii PhD
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  14. Takayoshi Tobe MD
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Additional information

This work was supported by a grant from the Ministry of Education, Japan (A-61440060).

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Sumi, S., Inoue, K., Kogire, M. et al. Effect of synthetic porcine neuropeptide Y (NPY) on splanchnic blood flows and Exocrine pancreatic secretion in dogs. Digest Dis Sci 36, 1523–1528 (1991). https://doi.org/10.1007/BF01296392

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  • DOI: https://doi.org/10.1007/BF01296392

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