Abstract
The effect of the H2-receptor antogonists cimetidine and ranitidine on pentagastrinstimulated gastric acid secretion in anesthetized rats, and gastric mucosal lesion formation and gastric motility in unanesthetized cold-restrained rats was studied. Both cimetidine and ranitidine suppressed pentagastrin-stimulated gastric secretion in a dose-dependent fashion. Cold restraint-induced lesion formation was not prevented with doses of both agents that inhibited acid secretion by 75%. Doses which suppressed pentagastrin-stimulated acid secretion more than 90% significantly prevented the development of gastric mucosal lesions produced by cold restraint. Doses of both H2 blockers which demonstrated significant suppression of lesion formation had no effect on cold restraint-stimulated gastric contractility. We conclude that cimetidine and ranitidine suppress cold restraint-induced lesion formation by suppressing acid secretion and not by suppressing gastric contractility.
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This Research supported by the Veterans Administration and a grant from Smith Kline & Erench Laboratories.
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Garrick, T., Goto, Y., Buack, S. et al. Cimetidine and ranitidine protect against cold restraint-induced ulceration in rat by suppressing gastric acid secretion. Digest Dis Sci 32, 1261–1267 (1987). https://doi.org/10.1007/BF01296376
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DOI: https://doi.org/10.1007/BF01296376