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Variability of cerebral blood fow deficits in99mTc-HMPAO SPECT in patients with Alzheimer's disease

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Summary

The purpose of this study was to analyse the frequency of the different pathological perfusion patterns in SPECT in a clinical, unselected population of patients with Alzheimer's disease. In 91 patients and 16 control subjects regional cerebral blood flow (rCBF) was measured with Single Photon Emission Computed Tomography (SPECT) using99mTc-hexa-methyl-propyleneamine oxime (HMPAO). 95% confidence intervals obtained from the perfusion values of the control subjects were used to define normal perfusion ranges.

The frequency of perfusion deficits in the left frontal, temporal, parietal and occipital lobes were 62.2%, 60.4%, 70.3% and 23.1%, respectively. In the right hemisphere the corresponding values were 60.4%, 58.2%, 63.7% and 9.9%. With the exception of the occipital lobes these frequencies were not significantly different. The analysis of the perfusion pattern of each patient revealed 35 different combinations of lobes with perfusion deficits. The temporo-parietal perfusion deficits were not more frequent than the temporo-frontal perfusion deficits. These results suggest that in the clinical routine a high variety of heterogeneous rCBF patterns have to be expected.

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Author notes

  1. R. Zimmer

    Present address: Department of Psychiatry, Technische Universität München, Germany

Authors and Affiliations

  1. Department of Psychiatry, Technische Universität München, Germany

    S. Leucht & H. Lauter

  2. Department of Nuclear Medicine, Technische Universität München, Germany

    U. Gebhardt

  3. Department of Internal Medicine, Kreiskrankenhaus Wasserburg, Wasserburg, Germany

    F. Schmauß

  4. National Institute of Mental Health, St. Elisabeth Hospital, Washington, DC, USA

    T. Rädler

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  1. R. Zimmer
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  2. S. Leucht
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  3. T. Rädler
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  4. F. Schmauß
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  5. U. Gebhardt
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  6. H. Lauter
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Zimmer, R., Leucht, S., Rädler, T. et al. Variability of cerebral blood fow deficits in99mTc-HMPAO SPECT in patients with Alzheimer's disease. J. Neural Transmission 104, 689–701 (1997). https://doi.org/10.1007/BF01291886

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  • DOI: https://doi.org/10.1007/BF01291886

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