Summary
Hyperthermic perfusion was used in 15 adult patients with soft tissue sarcoma of the limbs. Only patients were selected with prognostically unfavorable or recurrent tumors, which were excised with a limited safety margin. Three patients died from pulmonary metastases 16, 24, and 34 months after perfusion. In 2 patients a local recurrence developed. Ten patients are alive and free of recurrence. The follow-up period ranges from 7–47 months with a median of 30 months. These results encourage the further use of hyperthermic perfusion.
Zusammenfassung
Die hypertherme Perfusion wurde bei 15 Erwachsenen mit Weichteilsarkomen der Extremitäten eingesetzt. Perfundiert wurden nur Patienten mit prognostisch ungünstigen oder bereits rezidivierten Tumoren. 3 Patienten sind 16, 24 bzw. 34 Monate nach Perfusion an Lungenmetastasen verstorben. 2 Patienten bekamen ein Lokalrezidiv. 10 Patienten leben tumorfrei. Die Nachbeobachtungszeit beträgt 7–47 Monate, der Median 30 Monate. Die Ergebnisse ermutigen zu einem weiteren Einsatz der hyperthermen Perfusion.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literatur
Cantin J, McNeer GP, Chu FC, Booher RJ (1968) The problem of local recurrence after treatment of soft tissue sarcoma. Ann Surg 168:47
Hermanek P (1977) Klinische Pathologie der Weichteiltumoren. Chirurg 48:685
Karakousis CP, Rao U, Holtermann OA, Kanter PM, Holyoke ED (1979) Tourniquet infusion chemotherapy in extremities with malignant lesions. Surg Gynecol Obstet 149:481
Kern E (1977) Chirurgische Behandlung maligner Weichteiltumoren. Dtsch Arztebl 27:1757
Lindberg RD, Martin RG, Romsdahl MM (1975) Surgery and postoperative radiotherapy in the treatment of soft tissue sarcomas in adults. Am J Radiol 123:123
McBride CM (1974) Sarcomas of the limbs. Results of adjuvant chemotherapy using isolation perfusion. Arch Surg 109:304
Rosenberg StA et al (1978) Prospective randomized evaluation of the role of limb-sparing surgery, radiation therapy, and adjuvant chemoimmunotherapy in the treatment of adult soft-tissue sarcomas. Surgery 84:62
Russell WO, Cohan J et al (1977) A clinical and pathological staging system for soft tissue sarcomas. Cancer 40:1562
Schraffordt Koops H, Eibergen R, Oldhoff J, van der Ploeg E, Vermey A (1976) Isolated regional perfusion in the treatment of soft tissue sarcomas of the extremities. Clin Oncol2:245
Simon AA, Spanier SS, Enneking WF (1979) Management of adult soft-tissue sarcomas of the extremities. Surg Ann 11:363
Stchlin JS, de Ipolyi PD, Giovanella BC, Gutierrez AE, Anderson RF (1975) Soft tissue sarcomas of the extremity. Am J Surg 130:643
Suit HD, Russell WO, Martin RG (1973) Management of patients with sarcoma of soft tissue in an extremity. Cancer 31:1247
Tonak J (1981) Die hypertherme Zytostatikaperfusion beim malignen Melanom. Zuckschwerdt, München
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Tonak, J., Beck, H. 22. Die hypertherme Cytostaticaperfusion — eine adjuvante Therapie bei Weichteilsarkomen der Extremitäten. Langenbecks Arch Chiv 355, 157–160 (1981). https://doi.org/10.1007/BF01286832
Issue Date:
DOI: https://doi.org/10.1007/BF01286832