Skip to main content
SpringerLink
Log in

Electroconvulsive shock blocks the opioid-mediated inhibition of dopamine release in rat striatal slices

  • Published:
Journal of Neural Transmission Aims and scope Submit manuscript

Summary

The fractional release technique was applied to investigate the effects of single electroshock (ECS) on the opioid-mediated inhibition of dopamine release in rat striatal slices. Animals were submitted to ECS 24h before the experiments. The results demonstrate that pre-treatment with ECS suppresses the inhibition of dopamine release mediated by κ opioid receptors. These data suggest that single ECS treatment modifies the sensitivity of the κ opioid receptors located on the presynatic dopamine terminals in the rat striatum.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Balldin J, Granenis AK, Lindstedt G, Modigh K, Walinder J (1982) Neuroendocrine evidence for increased responsiveness of dopamine receptors in humans following electroconvulsive therapy. Psychopharmacology 76: 371–376

    PubMed  Google Scholar 

  • Carrasco MA, Diaz RD, Izquierdo I (1982) Naloxone reverses retrograde amnesia induced by electroconvulsive shock. Behav Neural Biol 34: 352–357

    PubMed  Google Scholar 

  • Fibiger HC (1990) The dopamine hypothesis of schizophrenia and mood disorders: contradiction and speculations. In: Willner PE, Schell-Kruger J (eds) The mesolimbic dopamine system: from motivation to action. Wiley, Chichester, p 1222

    Google Scholar 

  • Frenk H (1983) Pro- and anticonvulsant actions of morphine and the endogenous opioids: involvement and interactions of multiple opiate and non-opiate systems. Brain Res Rev 6: 197–210

    Google Scholar 

  • Green AR, Nutt DJ (1987) Psychopharmacology of repeated seizures: possible relevance to th mechanism of action of electroconvulsive therapy. In: Iversen LL, Iversen SD, Snyder SH (eds) Handbook of psychopharmacology. Plenum Press, New York, p 375

    Google Scholar 

  • Holaday JW, Belenky GL (1980) Opiate-like effects of electroconvulsive shock in rats: a differential effect of naloxone on nociceptive measures. Life Sci 27: 1929–1938

    PubMed  Google Scholar 

  • Mulder AH, Burger DM, Wardeh G, Hogenboom F, Frankhuijzeen AL (1991) Pharmacological profile of various κ, μ and δ-opioid receptor mediating presynaptic inhibition of neurotransmitter release in the brain. Eur J Pharmacol 102: 518–522

    Google Scholar 

  • Modigh K, Balldin J, Eriksson E, Granerus AK, Walinder J (1984) Increased responsiveness of dopamine receptor after ECT: a review of experimental and clinical evidence. In: Lerer B, Weiner RD, Belmaker RH (eds) ECT: basic mechanisms. Libbey, London, p 18

    Google Scholar 

  • Nomikos GG, Athanasios PZ, Damsma G, Fibiger HC (1991) Electroconvulsive shock produces large increases in interstitial concentrations of dopamine in the rat striatum: an in vivo microdialysis study. Neuropsychopharmacology 4: 65–69

    PubMed  Google Scholar 

  • Passarelli F, Orzi F (1993) Effects of electroconvulsive shock treatment on the opioid-mediated inhibiton of serotonin release in rat hippocampal slices. NeuroReport 4: 1108–1110

    PubMed  Google Scholar 

  • Passarelli F, Galzin AM, Langer SZ (1987) Interaction between neuronal uptake inhibitors and presynaptic serotonin autoreceptors in rat hypothalamic slices: comparison of K+ and electrical depolarization. J Pharmacol Exp Ther 242: 1056–1063

    PubMed  Google Scholar 

  • Przewlocka B, Lason W, Machelska H, vanLuijtelaar G, Coenen A, Przewlocki R (1995) Kappa opioid receptor agonists suppress absence seizures in WAG/Rij rats. Neurosci Lett 186: 131–134

    PubMed  Google Scholar 

  • Tortella FC (1988) Endogenous opioid peptides and epilepsy: quieting the seizing brain? Trends Pharmacol Sci 9: 366–372

    PubMed  Google Scholar 

  • Tortella FC, Long JB, Hong JS, Holaday JW (1989) Modulation of endogenous opioid systems by electroconvulsive shock. Convuls Ther 5: 261–273

    PubMed  Google Scholar 

  • Willner P (1983) Dopamine and depression: a review of recent evidence. III. The effects of antidepressant treatments. Brain Res Rev 6: 237–246

    Google Scholar 

  • Xie CW, Lee PHK, Takeuchi K, Owyang V, Li SJ, Douglass J, Hong JS (1989) Single or repeated electroconvulsive shocks alter the levels of prodynorphin and proenkephalin mRNAs in the rat brain. Mol Brain Res 6: 11–19

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. F. Passarelli

    Present address: Department of Neuroscience, University “La Sapienza”, Rome

Authors and Affiliations

  1. Department of Neuroscience, University “La Sapienza”, Rome

    E. Carmenini, L. Calò & F. E. Pontieri

  2. INM “Neuromed”, Pozzilli (IS), Italy

    F. Orzi & F. E. Pontieri

Authors
  1. F. Passarelli
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. Carmenini
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. Calò
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Orzi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. E. Pontieri
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Passarelli, F., Carmenini, E., Calò, L. et al. Electroconvulsive shock blocks the opioid-mediated inhibition of dopamine release in rat striatal slices. J. Neural Transmission 104, 805–810 (1997). https://doi.org/10.1007/BF01285549

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01285549

Keywords

Search

Navigation