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Vacuole biogenesis and protein transport to the plant vacuole: A comparison with the yeast vacuole and the mammalian lysosome

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Summary

The vacuole is often termed the lytic compartment of the plant cell. The yeast cell also possesses a vacuole containing acid hydrolases. In animal cells these enzymes are localized in the lysosome. Recent research suggests that there is good reason to regard these organelles as homologous in terms of protein transport. Although sorting motifs for the recognition of “vacuolar proteins” within the endomembrane system differ between the three organelles, there is an underlying similarity in targeting determinants in the cytoplasmic tails of Golgi-based receptors. In all three cases these determinants appear to interact with adaptins of clathrin-coated vesicles which ferry their cargo first of all to an endosomal compartment. The situation in sorting and targeting of plant vacuolar proteins is complicated by the fact that storage and lytic vacuoles may exist together in the same cell. The origin of these two types of vacuole is also a matter of some uncertanity.

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Abbreviations

AP:

assembly protein

ALP:

alkaline phosphatase

ARF:

adenosine diphosphate ribosylation factor

BiP:

immunoglobulin binding protein

CCV:

clathrin coated vesicle

CPY:

carboxypeptidase-Y

DPAP:

dipeptidyl aminopeptidase

ER:

endoplasmic reticulum

GApp:

Golgi apparatus

LAMPs:

lysosomal associated membrane protein(s)

LAP:

lysosomal acid phosphatase

LIMPs:

lysosomal integral membrane protein(s)

MPRs:

mannosyl 6-phosphate receptors

MVB:

multivesicular bodies

NSF:

N-ethylmaleimide sensitive fusion (protein)

PAT:

phosphinotricine acetyltransferase

PB:

protein body

PHA:

phytohemagglutinin

PM:

plasma membrane

PSV:

protein storage vacuole

SNAPs:

soluble NSF attachment protein(s)

SNAREs:

SNAP receptor(s)

TGN:

trans Golgi network

TIP:

tonoplast integral protein

VPS:

vacuolar protein sorting

ZIO:

zinc iodide/osmium

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Robinson, D.G., Hinz, G. Vacuole biogenesis and protein transport to the plant vacuole: A comparison with the yeast vacuole and the mammalian lysosome. Protoplasma 197, 1–25 (1997). https://doi.org/10.1007/BF01279880

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