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Apoptosis and redox homostasis: On a possible mechanism of action of Bcl-2

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Summary

We discuss the involvement of several mammalian redox systems in the regulation of apoptosis. We focus especially on the role that mitochondria and the still ill-characterized plasma membrane NADH-oxidoreductase system play in apoptosis. The latter system was shown to respond to downregulation of mitochondrial function; inhibition of either system induces apoptosis. Apoptosis induced by inhibitors of the oxidase involves both Bcl-2 and calcineurin, two proteins recently shown to be capable of forming a tight complex. We suggest that Bcl-2 acts as an antioxidant, but in an electron sense rather than in an oxygen sense.

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Abbreviations

GSH:

glutathione

GSSH:

glutathione disulfide

PARP:

poly(ADP-ribosyl)transferase

PMOR:

plasma membrane NADH-oxidoreductase

TNF:

tumour necrosis factor

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  1. Department of Biochemistry and Molecular Biology, Monash University, Wellington Road, 3168, Clayton, VIC, Australia

    A. Lawen, M. A. Baker & S. Malik

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Lawen, A., Baker, M.A. & Malik, S. Apoptosis and redox homostasis: On a possible mechanism of action of Bcl-2. Protoplasma 205, 10–20 (1998). https://doi.org/10.1007/BF01279288

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