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Platelet serotonin and interleukin-1β after sleep deprivation and recovery sleep in humans

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Summary

Sleep deprivation (SD) represents a well-established therapy for major depression. Recent findings suggest that the antidepressive effects of sleep deprivation are mediated at least in part by pro-serotoninergic mechanisms. Furthermore, SD has been demonstrated to modify different host defense activities. We therefore investigated the serotonin (5-HT) content in platelets, platelet density distribution and 5-HT-induced IL-1β release from platelets in 10 healthy men before and after total SD (TSD) as well as after recovery sleep. Blood samples were drawn on 3 consecutive days at 7.00 h, 13.00 h, and 19.00 h, respectively. In addition, the psychophysiological parameters tiredness and wakefulness were assessed.

After TSD the normal daily variation of IL-1β release with high morning levels and low evening levels was found to be significantly inverted. The release of IL-1β corresponded positively to the subjectively experienced tiredness of the probands. Analysis of platelet density distribution indicated a significant daily variation of low density platelets with low levels in the morning and high levels in the evening, which was absent after TSD. Our findings favour an increased pro-serotoninergic effect after TSD, which comprises respective variations of the host defense system, but is abolished by consecutive recovery sleep.

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Author notes

  1. C. Opper

    Present address: Institute of Physiological Chemistry, Philipps University, Marburg

Authors and Affiliations

  1. Institute of Physiological Chemistry, Philipps University, Marburg

    P. Heiser, B. Dickhaus, H. W. Clement, C. Hasse & W. Wesemann

  2. Department of Psychiatry and Psychotherapy, Philipps University, Marburg

    W. Schreiber & J. C. Krieg

  3. Department of Psychology, Justus Liebig University, Giessen, Federal Republic of Germany

    J. Hennig

Authors
  1. P. Heiser
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  2. B. Dickhaus
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  3. C. Opper
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  4. W. Schreiber
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  5. H. W. Clement
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  6. C. Hasse
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  9. W. Wesemann
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Heiser, P., Dickhaus, B., Opper, C. et al. Platelet serotonin and interleukin-1β after sleep deprivation and recovery sleep in humans. J. Neural Transmission 104, 1049–1058 (1997). https://doi.org/10.1007/BF01273318

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  • DOI: https://doi.org/10.1007/BF01273318

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