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Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects

  • Neurology • Original Article
  • Published:
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Abstract

Purpose

To evaluate correlations between serotonin transporter (SERT) uptake ability in human peripheral platelets and sleep bruxism (SB) frequency.

Methods

Subjects were consecutively recruited from sixth-year students at Okayama University Dental School. Subjects were excluded if they (1) were receiving orthodontic treatment, (2) had a dermatological disease, (3) had taken an antidepressant within 6 months, or (4) had used an oral appliance within 6 months. SB frequency was determined as the summary score of three consecutive night assessments using a self-contained electromyography detector/analyzer in their home. Fasting peripheral venous blood samples were collected in the morning following the final SB assessment. SERT amount and platelet number were quantified via an ELISA assay and flow cytometry, respectively. Functional SERT characterization, 5-hydroxytryptamine (5-HT) uptake, maximum velocity (V max), and an affinity constant (K m ) were assessed with a [3H] 5-HT uptake assay. The correlations between these variables and SB level were evaluated.

Results

Among 50 eligible subjects (26 males, mean age 25.4 ± 2.41 years), 7 were excluded because of venipuncture failure, smoking, and alcohol intake during the experimental period. A small but significant negative correlation between SB level and [3H] 5-HT uptake was observed (Spearman’s correlation R 2 = 0.063, p = 0.04). However, there were no significant correlations between SB level and total platelet amount, SERT, V max, and K m values (p = 0.08, 0.12, 0.71, and 0.68, respectively).

Conclusions

Platelet serotonin uptake is significantly associated with SB frequency, yet only explains a small amount of SB variability.

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Authors and Affiliations

  1. Department of Oral Rehabilitation and Regenerative Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan

    Hajime Minakuchi & Takuo Kuboki

  2. Department of Dental Pharmacology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8525, Japan

    Hajime Minakuchi, Chiharu Sogawa, Haruna Miki, Emilio S. Hara, Kenji Maekawa & Shigeo Kitayama

  3. Department of Dental Pharmacology, Matsumoto Dental University, 1780 Hiro-okagohbara, Shiojiri city, Nagano, 399-0781, Japan

    Norio Sogawa

  4. Department of Stomatgnathic Function and Occlusal Reconstruction, Institute of Biomedical Science, Clinical Dentistry, Tokushima University Graduate School, 3-18-15 Kuramoto, Tokushima City, 770-8504, Japan

    Yoshizo Matsuka

  5. Advanced Program in Orofacial Pain and Oral Medicine, Ostrow School of Dentistry, University of Southern California, 925 West 34th St., Los Angeles, CA, 90089, USA

    Glenn Thomas Clark

Authors
  1. Hajime Minakuchi
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  2. Chiharu Sogawa
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  3. Haruna Miki
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  4. Emilio S. Hara
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  5. Kenji Maekawa
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  6. Norio Sogawa
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  7. Shigeo Kitayama
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  8. Yoshizo Matsuka
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  9. Glenn Thomas Clark
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  10. Takuo Kuboki
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Corresponding author

Correspondence to Hajime Minakuchi.

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Funding

The Ministry of Education, Science and Culture, Japan, provided financial support in the form of Grant-in-Aid ((B) No. 23390442) and Grant-in-Aid for Exploratory Research (No. 25670819) . The sponsor had no role in the design or conduct of this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements) or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Minakuchi, H., Sogawa, C., Miki, H. et al. Sleep bruxism frequency and platelet serotonin transporter activities in young adult subjects. Sleep Breath 20, 271–276 (2016). https://doi.org/10.1007/s11325-015-1281-0

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  • DOI: https://doi.org/10.1007/s11325-015-1281-0

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