Summary
In experiments on live animals we have examined to what extent prophylactic applications of cimetidine and somatostatine are able to prevent stress-induced ulcer in the rat. 130 male Wistar strain rats were exposed to a combined immobilisation-immersion stress, cimetidine was given subcutaneously and somatostatin as a continuous intraperitoneal infusion. Results show that cimetidine produces no change in the average ulceration index (U. I.), nor in the transmural potential (P.D.). However, somatostatin significantly lowers the incidence rate of stress-induced gastric ulcers in rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Altemeier, W. A., Fullen, W. D., McDonough, J. J.: Sepsis and gastrointestinal bleeding. Ann. Surg.175, 759–770 (1972)
Arnold, R., Creutzfeldt, W.: Hemmung der pentagastrin-induzierten Säuresekretion des Magen beim Menschen durch Somatostatin. Dtsch. Med. Wochenschr.100, 1014–1016 (1975)
Benichoux, D., Raynov, M., Baptiste, D., Floquet, J., Benichoux, R.: Effects of cimetidine on the stress gastric ulcer of the rat. Abstracts 14th Congress European Society for Surgical Research, p. 18, Barcelona 1979
Bloon, S. R., Mortimer, Ch., Thorner, M. O., Berser, G. M., Hall, gnR., Gomez-Pan, A., Roy, V. M., Russell, R. C. G., Coy, D. U., Kastin, A. J.: Inhibition of gastrin and gastric-acid secretion by growth hormone release inhibiting hormone. Lancet1974II, 1106–1109
Bodily, K., Fischer, R. D.: The prevention of stress ulcers by metiamide, an H2-receptor antagonist. J. Surg. Res.20, 203–209 (1976)
Bowen, J. C., Yuh-Jyh Kno, Pawlik, W., Wiliams, D., Shanbour, L. L., Jacobson, E. D.: Electrophysiological effects of burimamide and 16,16-dimethyl-prostaglandin E2 on the canine gastric mucosa. Gastroenterology68, 1480–1484 (1975)
Curling, T. B.: An acute ulceration of the duodenum in cases of burn. Trans. R. Med. Chir. (Loud.)25, 260–261 (1842)
Garcia-Blanque, C.: Posibilidades terapeuticas en la ülcera gástrica por “stress”: Estudio experimental. Tesis doctoral, Universidad de Granada (1979)
Ivey, K. J., Clifton, J. A.: Back diffusion on hydrogen ions across gastric mucosa of patients with gastric ulcer and rheumatoid arthritis. Br. Med. J.01974 1, 16–19
Ivey, K. J., Jeffrey, G., Baskin, W.: Effect of cimetidine on gastric potential difference in man. Lancet1975 I, 1072–1073
Kontureck, S. J., Radecki, T., Pucher, A., Coy, D. H., Schally, A. V.: Effect of somatostatin on gastrointestinal secretions and peptic ulcer production in cats. Scand. J. Gastroenterol.12, 379383 (1977)
Mattes, P., Lauterbach, H. H., Raptis, S.: Prevention of stress ulcer by somatostatin in rats. Langenbecks Arch. Chir.341, 297–301 (1976)
Matsuo, Y., Seki, A.: Gastrin and effects of dogmatil (Sulpiride) on experimental ulcer. Vth Symp. Ther. New Drugs (Tokyo)105, 137–146 (1968)
Maza, J. M., Herrero, L. M., Revuelta, E., Res, E., Vara-Thorbeck, R.: Hemorragias digestivas secundarias a la agresión traumática. Arch. Fac. Med. (Madrid)31, 245–259 (1977)
Parsons, M. E.: The antagonism of histamine H2-receptors in vitro and in vivo with particular reference to the actions of cimetidine. In: Cimetidine: Proceedings of the Second International Symposium on Histamine H2-Receptor Antagonists. Eds.: Burland, W. L., Simkins, M. A., p.13. Amsterdam, Oxford: Excerpta Medica 1977
Pfeiffer, C. J.: Gastric-ulcer induced by immobilitation and water-immersion stress. Progress peptic ulcer. Ed.: Mozsik, Javor, p.84. Budapest: Akad. Kiádo. Paradfürdo. 1971
Raptis, S., Dellinger, H. C., von Berger, L., Schlegel, W., Schröder, K.E., Pfeiffer, E. F.: Effects of somatostatin on gastric secretion and release in man. Digestion13, 15–26 (1975)
Richardson, C. T., Walsh, J. H., Hicks, M. I.: The effect of cimetidine a new histamine H2-receptor antagonist, on meal-stimulated acid secretion, serum gastrin, and gastric emptying in patients with duodenal ulcer. Gastroenterology71, 19–23 (1976)
Swan, J.: Practical observations: case of a severe burn. Edin. Med. Surg. J.19, 344–345 (1823)
Vara-Thorbeck, R., Ros, E., Maza, J. M.: Tratamiento quirúrgico de la complicaeión hemorrágica en ulceras duodenales crónicas. Arch. Fac. Med. (Madrid)29, 267–279 (1976)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vara-Thorbeck, R., Garcia-Blanque, C. & Villen, A. Prevention of stress ulcer by cimetidine and somatostatin in rats. Langenbecks Arch Chiv 351, 215–218 (1980). https://doi.org/10.1007/BF01262713
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01262713