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Somatic Pain Sensitivity in Rats Exposed to the Harmful Actions of Indomethacin on the Gastrointestinal Tract

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The aim of the present work was to investigate somatic pain sensitivity in conscious rats exposed to the harmful actions of indomethacin on the gastrointestinal tract (GIT). Indomethacin was given at an ulcerogenic dose (35 mg/kg, s.c.) to previously starved (24 h) and sated (not starved) rats. Somatic pain sensitivity was evaluated in terms of the latent period (LP) of the pain reaction induced by thermal stimulation of the tail (the tailflick test). LP was tested during the formation of erosions in the stomach (1–4 h after indomethacin administration) and during the formation of lesions in the small intestine (24, 48, and 72 h after drug administration). Indomethacin administration induced gastric erosions at 4 h only in starved rats, but produced lesions in the small intestine at 24, 48, and 72 h both starved and sated rats. Lesions in both the stomach and the small intestine were accompanied by increases in the LP of the pain reaction. There were no increases in LP when indomethacin administration did not have marked damaging effects on the GIT. Development of the pathological process in the GIT was accompanied by symptoms of chronic stress: a prolonged increase in the blood corticosterone level, adrenal hypertrophy, thymus involution, and weight loss. Thus, somatic pain sensitivity was reduced in conscious rats exposed to the harmful effects of indomethacin on the stomach and intestine.

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Authors and Affiliations

  1. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    N. I. Yarushkina, T. R. Bagaeva & L. P. Filaretova

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  1. N. I. Yarushkina
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  2. T. R. Bagaeva
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  3. L. P. Filaretova
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Correspondence to N. I. Yarushkina.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 100, No. 1, pp. 73–85, January, 2014.

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Yarushkina, N.I., Bagaeva, T.R. & Filaretova, L.P. Somatic Pain Sensitivity in Rats Exposed to the Harmful Actions of Indomethacin on the Gastrointestinal Tract. Neurosci Behav Physi 45, 780–788 (2015). https://doi.org/10.1007/s11055-015-0144-2

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