Summary
From the inbred rat strains F344, LEW and Brown-Norway (BN), the following combinations were formed: syngeneic (LEW-LEW), weakly allogeneic (F344-LEW) and strongly allogeneic (BN-LEW). A small intestine segment was transplanted using the by-pass technique; after 10 days the graft was removed and histologically investigated. The strongest rejection was found in the lymphatic tissue and the epithelium of the small intestinal transplant. The immunogenetical difference is significant for the survival of the graft: the greater the immunogenetical difference between donor and host, the more severe the morphologically demonstrable rejection reaction.
Zusammenfassung
Aus den Ratteninzuchtstämmen F344, LEW und Brown-Norway (BN) wurden eine syngene (LEW-LEW), schwach (F344-LEW), und eine stark allogene (BN-LEW) Stammkombination gebildet. Der nach Bypasstechnik transplantierte Dünndarm wurde nach 10 Tagen entnommen zur histologischen Untersuchung. Die stärksten Abstoßungsreaktionen sind in den Lymphgeweben und den Epithelien des Dünndarmtransplantates sichtbar. Die immunogenetische Differenz ist entscheidend für den Erhaltungszustand des Transplantates. Je größer die Differenz zwischen Spender und Empfänger ist, desto heftiger ist die morphologisch nachgewiesene Abstoßungsreaktion.
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Thiede, A., Deltz, E. Morphological reaction in transplanted small intestines using immunogenetically defined rat strain combinations. Langenbecks Arch Chiv 346, 119–127 (1978). https://doi.org/10.1007/BF01261398
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DOI: https://doi.org/10.1007/BF01261398