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Antigenic relationship between human cytomegalovirus. Herpes simplex, and Varieella-Zoster virus studied by complement-fixation

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Summary

The antigenic relationship between CMV, HSV, and VZV viruses was studied by the complement-fixation. 47 sera from congenitally infected children excreting CMV regularly possessed homologous antibodies, mostly at titers of 1 in 60 or more. HSV antibodies were found in 9 sera from children older than one year, but only 3 sera showed antibody titers of 1 in 60 or more. VZV antibodies were detected, at low titers, in 3 sera from infants under one year of age.

Six sera from adults with postnatal CID excreting CMV showed regularly both CMV and HSV antibodies, although CMV antibodies were of slightly higher titers. VZV antibodies were found in 2 adults at low titers.

Paired sera from 4 patients with significant titer rises against CMV did not show titer rises against heterologous antigens. Also, 4 serum pairs from patients with titer rises against HSV did not cross-react with either CMV or VZV antigens.

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  1. U. Krech

    Present address: Institute of Bacteriology, St. Gall, Switzerland

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  1. Institute of Bacteriology, St. Gall, Switzerland

    M. Jung

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  1. U. Krech
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  2. M. Jung
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Supported by Grant No. 4449 from the “Schweizerischer Nationalfonds zur Förderung der wissenschaftlichen Forschung”.

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Krech, U., Jung, M. Antigenic relationship between human cytomegalovirus. Herpes simplex, and Varieella-Zoster virus studied by complement-fixation. Archiv f Virusforschung 33, 288–295 (1971). https://doi.org/10.1007/BF01254685

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  • DOI: https://doi.org/10.1007/BF01254685

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