Skip to main content
SpringerLink
Log in

The effect of methamphetamine on serotonin and its metabolite in the suprachiasmatic nucleus: A microdialysis study

  • Full Papers
  • Published:
Journal of Neural Transmission / General Section JNT Aims and scope Submit manuscript

Summary

The suprachiasmatic nucleus (SCN) has been identified as a major circadian pacemaker. Methamphetamine has been shown to modify the behavior of circadian rhythms. We detected extracellular serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the SCN in freely moving rats, using a microdialysis method, to investigate biochemical effects of methamphetamine in the SCN. Methamphetamine infusion into the SCN dose-dependently increased extracellular 5-HT and decreased extracellular 5-HIAA.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Azimitia EC, Segal M (1978) An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol 179: 641–659

    PubMed  Google Scholar 

  • Duncan WC, Wehr TA (1988) Pharmacological and nonpharmacological chronotherapies of depression, In: Reinberg A, Smolensky M, Labrecque G (eds) Annual review of chronopharmacology, vol 4. Pergamon, Oxford, pp 137–170

    Google Scholar 

  • Faradji H, Cespuglio R, Jouvet M (1983) Voltammetric measurements of 5-hydroxyindole compounds in the suprachiasmatic nucleus: circadian fluctuations. Brain Res 279: 111–119

    PubMed  Google Scholar 

  • Hernandez LF, Hoebel BG (1987) Simultaneous microdialysis and amphetamine infusion in the nucleus accumbens and striatum of freely moving rats: increase in extracellular dopamine and serotonin. Brain Res Bull 19: 623–628

    PubMed  Google Scholar 

  • Honma K, Honma S, Hiroshige T (1986) Disorganization of the rat activity rhythm by chronic treatment with treatment with methamphetamine. Physiol Behav 38: 95–109

    PubMed  Google Scholar 

  • Ikeda Y, Chiba Y (1982) Effects of psychotropics on circadian motor activity in rats, In: Takahashi R, Halberg F, Walker CA (eds) Advances in the biosciences, vol 41. Toward chronopharmacology. Pergamon, New York, pp 3–10

    Google Scholar 

  • Levine JD, Rosenwasser AM, Yanovsky JA, Adler NT (1986) Circadian activity rhythms in rats with midbrain raphe lesions. Brain Res 384: 240–249

    PubMed  Google Scholar 

  • Meijer JH, Groos GA (1988) Responsiveness of suprachiasmatic and ventral lateral geniculate neurons to serotonin and imipramine: a microiontophoretic study in normal and imipramine-treated rats. Brain Res Bull 20: 89–96

    PubMed  Google Scholar 

  • Meyer DC (1978) Hypothalamic and raphe serotonergic systems in ovulation control. Endocrinology 103: 1067–1074

    PubMed  Google Scholar 

  • Moore RY (1983) Organization and function of a central nervous sysem circadian oscillator: the suprachiasmatic hypothalamic nucleus. Fed Proc 42: 2783–2789

    PubMed  Google Scholar 

  • Nakahara D, Ozaki N, Nagatsu T (1989) A removable brain microdialysis probe unit for in vivo monitoring of neurochemical activity. Biogenic Amines 6: 559–564

    Google Scholar 

  • Omata K, Kawamura H (1988) Effects of methamphetamine upon circadian rhythms in multiple unit activity inside and outside the suprachiasmatic nucleus in the golden hamster. Neurosci Lett 95: 897–902

    Google Scholar 

  • Parada ML, Hernandez L, Schwarz D, Hoebel BG (1988) Hypothalamic infusion of amphetamine increases serotonin, dopamine and norepinephrine. Physiol Behav 44: 607–610

    PubMed  Google Scholar 

  • Paxinos G, Watson C (1986) The rat brain in stereotaxic coordinates, 2nd ed. Academic Press, Sydney

    Google Scholar 

  • Rusak B, Zucker I (1979) Neural regulation of circadian rhythms. Physiol Rev 59: 449–526

    PubMed  Google Scholar 

  • Saavreda JM, Pakovitz M, Brownstein MJ, Axelrod J (1974) Serotonin distribution in the nuclei of the rat hypothalamus and preoptic region. Brain Res 77: 157–165

    PubMed  Google Scholar 

  • Szafarczyk A, Alonso G, Ixart G, Malaval F, Nouguier-Soule J, Assenmacher I (1980) The serotonergic system and the circadian rhythms of ACTH and corticosterone in rats. Am J Physiol 239: E482-E489

    PubMed  Google Scholar 

  • Wirz-Justice A, Groos GA, Wehr TA (1982) The neuropharmacology of circadian time-keeping in mammals. In: Ashoff J, Daan S, Groos GA (eds) Vertebrate circadian systems, structure and physiology. Springer, Berlin Heidelberg New York, pp 183–193

    Google Scholar 

  • Wood AJ, Goodwin GM (1987) A review of the biochemical and neuropharmacological actions of lithium. Psychol Med 17: 579–600

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. N. Ozaki

    Present address: Department of Psychiatry, Nagoya University School of Medicine, Nagoya, Japan

Authors and Affiliations

  1. Department of Psychiatry, Nagoya University School of Medicine, Nagoya, Japan

    Y. Kasahara

  2. Department of Biochemistry, Nagoya University School of Medicine, Nagoya, Japan

    T. Nagatsu

  3. Department of Psychology, Nagoya University College of Medical Technology, Nagoya, Japan

    D. Nakahara

Authors
  1. N. Ozaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Nakahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Y. Kasahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Nagatsu
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ozaki, N., Nakahara, D., Kasahara, Y. et al. The effect of methamphetamine on serotonin and its metabolite in the suprachiasmatic nucleus: A microdialysis study. J. Neural Transmission 86, 175–179 (1991). https://doi.org/10.1007/BF01250703

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01250703

Keywords

Search

Navigation