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The genetic relationship between thermostability of poliovirus and its in vivo response to cystine

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Summary

The relationships among three genetic properties (inhibition by cystine, thermostability, and cystine-requirement) of antigenic type 1 poliovirus were investigated. Partial or complete loss through mutation of the property of being inhibited by cystine was accompanied by changes in the other two properties, indicating that the genetic element(s) which determines inhibition by cystine also determines, at least partially, thermostability and cystine-requirement. Inhibition by cystine and thermostability were found to be closely and positively correlated, suggesting that they are simply different manifestations of a single more basic virus property.

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Authors and Affiliations

  1. Hixon Memorial Laboratory, Department of Pediatrics, University of Kansas School of Medicine, Kansas City, Kansas, USA

    George R. Dubes, Margaret Chapin & Otis Tolbert

Authors
  1. George R. Dubes
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  2. Margaret Chapin
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  3. Otis Tolbert
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Additional information

This research was aided by a grant from the National Foundation.

Part of these results were given on September 1, 1959, at a meeting of the Genetics Society of America at Pennsylvania State University, University Park, Pennsylvania, U.S.A., and have appeared in abstract form (1).

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Dubes, G.R., Chapin, M. & Tolbert, O. The genetic relationship between thermostability of poliovirus and its in vivo response to cystine. Archiv f Virusforschung 10, 315–334 (1960). https://doi.org/10.1007/BF01250678

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  • DOI: https://doi.org/10.1007/BF01250678

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