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Coxsackie A7 virus infections of rodents

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Summary

Coxsackie A7 virus injected by various routes caused fatal paralytic disease in newborn mice, adult merions and adult cotton rats. In all these species, and also in adult mice and lemmings with silent infections, brown fat was infectious during the first few days after inoculation. Virus titres of brown fat were higher than those of other organs and gross and microscopic evidence of necrosis was seen in cotton rats infected with virus strains isolated in Scotland but not with the Russian ABIV strain. Brown fat is susceptible to many neurotropic viruses, and it may act to increase the severity of the infection or provide a model of the infectious process suitable for study.

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Author notes

  1. N. R. Grist (Professor of Infectious Diseases)

    Present address: Regional Virus Laboratory and Department of Pathology, Ruchill Hospital, Glasgow, Scotland

  2. G. B. S. Roberts (Lecturer in Pathology)

    Present address: Ayrshire Area Laboratory, Ballochmyle Hospital, Mauchline, Ayrshire

Authors and Affiliations

  1. Regional Virus Laboratory and Department of Pathology, Ruchill Hospital, Glasgow, Scotland

    G. B. S. Roberts (Lecturer in Pathology)

  2. University of Glasgow, Scotland

    N. R. Grist (Professor of Infectious Diseases) & G. B. S. Roberts (Lecturer in Pathology)

Authors
  1. N. R. Grist
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  2. G. B. S. Roberts
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Grist, N.R., Roberts, G.B.S. Coxsackie A7 virus infections of rodents. Archiv f Virusforschung 19, 454–463 (1966). https://doi.org/10.1007/BF01250613

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  • DOI: https://doi.org/10.1007/BF01250613

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