Summary
Amphetamine increased the response of rabbit aortic strips to adrenaline, dopamine and serotonin at consistently lower doses than those exerting a direct contracting effect. The amphetamine-facilitated contraction had the same shape as that produced by biogenic amines alone, whereas the contraction produced by amphetamine alone was more delayed and flatter. Serotonin and dopamine facilitated each other, but less markedly and with a narrower interval between facilitating and contracting doses than amphetamine. Pargyline exerted no facilitating effect on biogenic amines. Phentolamine and prazosin inhibited the direct response to adrenaline, dopamine and amphetamine, and the amphetamine-facilitated response to adrenaline and dopamine; they were inactive against serotonin alone and combined with a facilitating dose of amphetamine or dopamine. Cyproheptadine inhibited the direct response to serotonin and amphetamine, and the amphetamine-facilitated response to serotonin; it was inactive against dopamine and adrenaline both alone and combined with a facilitating dose of amphetamine or serotonin.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Angrist BM, Sathanathan GS, Gershon S (1973) Behavioural effects of L-DOPA in schizophrenic patients. Psychopharmacology (Berlin) 31: 1–12
Apperly E, Humphrey PPA, Levy GP (1976) Receptors for 5-hydroxytryptamine and noradrenaline in rabbit isolated ear artery and aorta. Br J Pharmacol 58: 211–221
Azzaro AJ, Rutledge CO (1973) Selectivity of release of norepinephrine, dopamine and 5-hydroxytryptamine by amphetamine in various regions of rat brain. Biochem Pharmacol 22: 2801–2813
Bevan JA, Duckels SP, Lee TJF (1975) Histamine potentiation of nerve- and drug-induced response of a rabbit cerebral artery. Circ Res 36: 653–674
Carroll PR, Ebeling PW, Glover WE (1974) The responses of the human temporal and rabbit ear artery to 5-hydroxytryptamine and some of its antagonists. Aust J Exp Biol Med 52: 813–823
Dela Lande IS, Cannel VA, Waterson JG (1966) Interaction of serotonin and noradrenaline on the perfused artery. Br J Pharmacol Chem 28: 255–272
Dubokovich ML, Zahniser NR (1985) Binding characteristics of dopamine uptake inhibitor H-nomifensine to striatal membranes. Biochem Pharmacol 34: 1137–1144
Garcia R, Thibault G, Seidah NG, Lazure C, Cantin M, Genest J, Chretien M (1985) Structure-activity relationships of atrial natriuretic factor (ANF). II. Effect of chainlength modifications on vascular reactivity. Biochem Biophys Commun 126: 178–184
Green AL, El Hait MJ (1978) Inhibition of mouse brain monoamine oxidase by (+)-amphetamine in vivo. J Pharm Pharmacol 30: 262–263
Heikkila RE, Orlansky H, Cohen G (1975) Studies on the distinction between uptake inhibition and release of H-dopamine in rat brain tissue slices. Biochem Pharmacol 34: 1137–1144
Javitch JA, Blaustein RO, Snyder SH (1984) H-mazindol binding associated with neuronal dopamine and norepinephrine uptake sites. Mol Pharmacol 26: 35–44
Kamal LA, Arbilla S, Langer SZ (1981) Presynaptic modulation of the release of dopamine from the rabbit caudate nucleus: differences between electrical stimulation, amphetamine and tyramine. J Pharmacol Exp Ther 214: 592–598
Linton W, Gallo PS jr (1975) The practical statistician: simplified handbook of statistics. Wadsworth Publishing Company, Belmont, California
Mantle TJ, Tipton KF, Garret NJ (1976) Inhibition of monoamine-oxidase by amphetamine and related compounds. Biochem Pharmacol 25: 2073–2077
Meehan AG, Rand MJ, Medgett IC (1986) Effects of serotonin on sympathetic noradrenergic transmission in rabbit isolated ear artery. J Cardiovasc Pharmacol 8: 1144–1153
Moritoki H, Su C (1981) Potentiating effects of 5-hydroxytryptamine and histamine on nerve stimulation-induced contractions of the rabbit mesenteric artery. Arch Int Pharmacodyn 252: 186–195
Parker EM, Cubeddu LX (1986) Effects of d-amphetamine and dopamine synthesis inhibitors on dopamine and acetylcholine neurotransmission in the striatum. 1. Release in the absence of vesicular transmitter stores. J Pharmacol Exp Ther 273: 179–192
Scheel-Kruger J (1971) Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the catecholamines in the brain. Eur J Pharmacol 14: 47–59
Silvestrini B, Palmery M, Severini C (1988) Effects of D-lysergic acid diethylamine on serotonin, adrenaline and dopamine evoked aorta contractions. Pharmacol Res Commun 20: 435–436
Takimoto GS, Cho AK, Schaeffer JC (1977) Inhibition of norepinephrine accumulation by amphetamine derivates: studies with rat brain and rabbit aorta. J Pharmacol Exp Ther 202: 267–277
Tallarida RJ, Murray RB (1987) Manual of pharmacological calculations with computer programs. Springer, Berlin Heidelberg New York
Uretsky NJ, Snodgrass SR (1977) Studies on the mechanism of stimulation of dopamine synthesis by amphetamine. J Pharmacol Exp Ther 202: 565–580
Van Nueten JM, Janssen PAJ, Van Beek J, Xhonneux R, Verbeuren TJ, Vanhoutte PM (1981) Vascular effects of ketanserin (R41468) a novel antagonist of 5-HT serotoninergic receptors. J Pharmacol Exp Ther 218: 217–230
Van Nueten JM, Janssen PAJ, De Ridder W, Vanhoutte PM (1982) Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in isolated femoral artery of the rabbit; effect of ketanserin (R41468). Eur J Pharmacol 77: 281–287
Author information
Authors and Affiliations
Additional information
Submitted as a preliminary communication to the SIF — XXV Congress held in Taormina, October, 14–18, 1990
Rights and permissions
About this article
Cite this article
Silvestrini, B., Palmery, M., Basta, F. et al. Facilitating effect of amphetamine on the response of rabbit aortic strips to adrenaline, dopamine and serotonin. J. Neural Transmission 86, 51–59 (1991). https://doi.org/10.1007/BF01250375
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01250375