Summary
The antigenicity and protective effect of 3 strains of avian infectious bronchitis virus inactivated by beta-propiolactone were studied. Chickens administered 2 doses of the inactivated Connecticut strain (IBV-46) vaccine by aerosol at 3-week intervals had significant levels of virus-neutralizing antibodies and were resistant to infection by the Massachusetts strain (IBV-41) as determined by virus isolation attempts. Antibody levels in chickens given inactivated Iowa 33 and Iowa 609 were not significant and they were not resistant to infection by IBV-41.
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Coria, M.F. Protective effect of an inactivated avian coronavirus vaccine administered by aerosol. Archiv f Virusforschung 41, 66–70 (1973). https://doi.org/10.1007/BF01249930
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DOI: https://doi.org/10.1007/BF01249930