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Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption

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Summary

The acceleration in brain serotonin synthesis produced by injecting rats with tryptophan or allowing them to consume a carbohydrate diet was not blocked by the prior elevation of brain serotonin levels (by administration of a MAO inhibitor: Lilly 516411) or by a treatment (chlorimipramine administration) that decreases impulse flow along serotoninergic neurons.

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  1. R. J. Wurtman

    Present address: Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

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  1. Laboratory of Neuroendocrine Regulation, Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA

    J. H. Jacoby & J. L. Colmenares

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  1. J. H. Jacoby
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  2. J. L. Colmenares
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  3. R. J. Wurtman
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Jacoby, J.H., Colmenares, J.L. & Wurtman, R.J. Failure of decreased serotonin uptake or monoamine oxidase inhibition to block the acceleration in brain 5-hydroxyindole synthesis that follows food consumption. J. Neural Transmission 37, 25–32 (1975). https://doi.org/10.1007/BF01249763

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  • DOI: https://doi.org/10.1007/BF01249763

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