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An interferon-like inhibitor of foot-and-mouth disease virus induced by phytohemagglutinin in swine leukocyte culturesb

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Summary

An inhibitor of foot-and-mouth disease virus was produced in cultures of swine leukocytes following treatment with phytohemagglutinin. Marked reduction in virus titer and mean plaque size was found following overnight incubation of primary bovine or swine kidney monolayers with clarified swine leukocyte media pretreated with PHA prior to virus infection. The biological and physical properties of this inhibitor suggest it has many properties similar to those of an interferon.

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References

  1. Dinter, Z., andL. Philipson: An interferon produced by foot-and-mouth disease virus (FMDV) in calf kidney cells. Proc. Soc. exp. Biol. (N.Y.)109, 893 (1962).

    Google Scholar 

  2. Sellers, R. F., J. H. Bennett, G. N. Mowat, andW. A. Snowdon: Some factors affecting interferon production by foot-and-mouth disease virus in bovine tissue cultures. Arch. ges. Virusforsch.23, 1 (1968).

    Google Scholar 

  3. Wheelock, E. F.: Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. Science149, 310 (1965).

    Google Scholar 

  4. Martinsen, J. S.: Effect of diethylaminoethyl-dextran on plaque formation of two plaque size variants of foot-and-mouth disease virus. In preparation (1968).

  5. Bachrach, H. L., J. J. Callis, W. R. Hess, andR. E. Patty: A plaque assay for foot-and-mouth disease virus and. kinetics of virus reproduction. Virology4, 224 (1957).

    Google Scholar 

  6. Tubiash, H. S.: Quantity production of leukocyte cultures for use in hemadsorption tests with African Swine Fever Virus. Amer. J. vet. Res.24, 381 (1963).

    Google Scholar 

  7. Ho, M.: Identification and “induction” of interferon. Bact. Eev.28, 367 (1964).

    Google Scholar 

  8. Lockart, R. Z.: Biological properties of interferons; criteria for acceptance of a viral inhibitor as an interferon. In Interferons, pp. 1–20, New York: John Wiley and Sons, Inc., 1966.

    Google Scholar 

  9. Finter, N. B.: Quantitative haemadsorption, a new assay technique. 1. Assay of interferon. Virology24, 589 (1964).

    Google Scholar 

  10. Ho, M., K. H. Fantes, D. C. Burke, andN. B. Finter: Interferons or interferon-like inhibitors induced by non-viral substances. In Interferons, pp. 181–201, New York: John Wiley and Sons, Inc., 1966.

    Google Scholar 

  11. Edelman, R., andE. F. Wheelock: Specific role of each human leukocyte type in viral infections. II. Phytohemagglutinin-treated lymphocytes as host cells for vesicular stomatitis virus replicationin vitro. J. Virol.2, 440 (1968).

    Google Scholar 

  12. Ripps, C. S., andK. Hirschhorn: The production of immunoglobulins by human peripheral blood lymphocytesin vitro. Clin. exp. Immunol.2, 377 (1967).

    Google Scholar 

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Author notes

  1. J. Y. Richmond

    Present address: Animal Disease and Parasite Research Division, Agricultural Research Service, U.S. Department of Agriculture, Plum Island Animal Disease Laboratory, Greenport, Long Island, NY, USA

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    1. J. Y. Richmond
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    This work was conducted while in pursuance of a Postdoctoral Resident Research Associateship of the Agricultural Research Service and the National Academy of Sciences — National Research Council.

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    Richmond, J.Y. An interferon-like inhibitor of foot-and-mouth disease virus induced by phytohemagglutinin in swine leukocyte culturesb. Archiv f Virusforschung 27, 282–289 (1969). https://doi.org/10.1007/BF01249650

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    • DOI: https://doi.org/10.1007/BF01249650

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