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The influence of zinc on bone healing in rats

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Summary

The importance and necessity of the trace element zinc for tissue restitution after injuries has been known for a long time. The influence of zinc on the healing of tibial fractures in rats is studied by daily administration of 0.6 mg zinc-dl-aspartate compared to a non-treated control group. There is a significant decrease of bone-zinc concentration after fracture. This decrease can be balanced out by zinc administration. There are no significant alterations in serum levels of zinc in both groups. Fracture healing is not affected. Zinc accumulates in bones.

Zusammenfassung

Die Bedeutung and Notwendigkeit des Spurenelementes Zink fur reparative Vorgänge im Organismus ist seit langem bekannt. In einer ersten tier-experimentellen Untersuchung wird der Einfluß von Zink auf die Heilung einer Tibiafraktur bei der Ratte nach täglicher Zufuhr von 0,6 mg Zink-DL-Aspartat im Vergleich zu einer unbehandelten Kontrollgruppe untersucht. Dabei zeigt sich ein statistisch signifikanter Abfall der Zinkkonzentration im Knochen bei Fraktur, der durch die Zinkzufuhr ausgeglichen werden kann. Die Serumzinkwerte zeigen keine statistisch signifikanten Unterschiede in beiden Gruppen. Eine Verkür-zung der Knochenbruchheilungszeit tritt nicht ein. Der Knochen dient als Zinkspeicher.

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Authors and Affiliations

  1. Chirurgische Klinik A der Universität Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany

    K. Milachowski, D. Moschinski, R. Jaeschock & A. Kaschner

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  1. K. Milachowski
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  2. D. Moschinski
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  3. R. Jaeschock
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  4. A. Kaschner
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Milachowski, K., Moschinski, D., Jaeschock, R. et al. The influence of zinc on bone healing in rats. Arch. Orth. Traum. Surg. 96, 17–21 (1980). https://doi.org/10.1007/BF01246137

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