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Spectrophotometric method for the determination of demeclocycline using sodium molybdate as analytical reagent

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Abstract

By means of spectroscopic methods it has been found that demeclocycline reacts with molybdate ions forming a complex compound [MoO3HDMTC]2−. The relative stability constant of this compound has been determined by applying spectrophotometric methods. Under optimum conditions for complex formation a very sensitive spectrophotometric method for the estimation of demeclocycline in the concentration range 5.0–35.1 μg/ml is proposed. The detection limit of the method is 2.5 μg/ml of demeclocycline. The relative standard deviation (n=10) varies between 0.76% and 1.46%. The method proved to be accurate and sensitive for the analysis of the demeclocycline content in tablets.

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Authors and Affiliations

  1. Institute of Analytical Chemistry, Faculty of Pharmacy, University of Belgrade, YU-11000, Belgrade, Yugoslavia

    Milena Jelikić-Stankov

  2. Department of Biochemistry, Clinical Center “Dr. Dragiša Misović”, YU-11000, Belgrade, Yugoslavia

    Dejan Stankov

  3. Institute of Physical Chemistry, Faculty of Pharmacy, University of Belgrade, YU-11000, Belgrade, Yugoslavia

    Dušan Malešev & Zorica Radović

Authors
  1. Milena Jelikić-Stankov
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  2. Dejan Stankov
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  3. Dušan Malešev
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  4. Zorica Radović
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Jelikić-Stankov, M., Stankov, D., Malešev, D. et al. Spectrophotometric method for the determination of demeclocycline using sodium molybdate as analytical reagent. Mikrochim Acta 103, 65–70 (1991). https://doi.org/10.1007/BF01245053

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  • DOI: https://doi.org/10.1007/BF01245053

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