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Colorimetric determination of some important hydrazine derivatives

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Abstract

A simple and rapid colorimetric method for the determination of isoniazid, isocarboxazid, iproniazid phosphate, phenelzine sulphate and phenylhydrazine hydrochloride is described. The method is based on the formation of ferroin, when the studied drugs react with a mixture of iron (III) and 1,10-phenanthroline, and measurement of the absorbance at 512 nm. The procedure has been successfully applied to the assay of the pharmaceutical preparations of the studied drugs and the results are favorably comparable to the official methods.

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References

  1. W. O. Foye,Principles of Medicinal Chemistry, Lea & Febiger, Philadelphia, 1976, pp. 288, 688.

    Google Scholar 

  2. The Merck Index, An Encyclopedia of Chemicals, Drugs and Biologicals, 10th Ed., 1983, p. 7176.

  3. British Pharmacopoeia, The Pharmaceutical Press, London, 1968, p. 1156.

  4. British Pharmacopoeia, HM Stationary Office, London, 1988.

  5. The United States Pharmacopeia XXII, National Formulary XVII, US Pharmacopeial Convention, Rockville, MD, 1990.

  6. R. Soliman, S. A. Belal,Pharmazie 1974,29, 204.

    Google Scholar 

  7. Y. A. Beltagy, A. S. Issa, M. S. Mahrous,Talanta 1978,25, 349.

    Google Scholar 

  8. B. N. Sarkar,Indian J. Pharm. 1972,24, 58.

    Google Scholar 

  9. S. R. El-Shabouri, S. A. Ibrahim, A. F. Youssef,Int. J. Pharm. 1979,2, 257.

    Google Scholar 

  10. J. T. Stewart, D. A. Settle,J. Pharm. Sci. 1975,64, 1403.

    Google Scholar 

  11. F. A. Ibrahim, M. S. Rizk, F. Belai,Analyst 1986,111, 1285.

    Google Scholar 

  12. M. E. El-Kommos, A. S. Yanni,Analyst 1988,113, 1091.

    Google Scholar 

  13. J. Bartos,Ann. Pharm. Fr. 1971,29, 71.

    Google Scholar 

  14. Y. Kidani, K. Inagoki, T. Saotome, H. Koike,Bunseki Kagaku 1973,22, 896.

    Google Scholar 

  15. J. J. Vallon, A. Badinand, C. Bichon,Anal. Chim. Acta 1975,78, 93.

    Google Scholar 

  16. Z. I. El-Darawy, H. K. El-Makkawi, T. M. H. Saber,Pharmazie 1975,30, 94.

    Google Scholar 

  17. V. J. Jennings, A. Dodson, A. Harrison,Analyst 1974,99, 145.

    Google Scholar 

  18. A. Calo, C. Cardini, V. Quercia,Boll. Chim. Farm. 1968,107, 296.

    Google Scholar 

  19. J. T. Stewart, I. L. Honigberg, J. P. Brant, W. A. Murray, J. L. Webb, J. B. Smith,J. Pharm. Sci. 1976,65, 1536.

    Google Scholar 

  20. J. D. Hinchen,Practical Statistics for Chemical Research, Methuen, London, 1969.

    Google Scholar 

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Authors and Affiliations

  1. Department of Analytical Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

    Amina M. El-Brashy, Fawzia A. Ibrahim & Saadia M. El-Ashry

Authors
  1. Amina M. El-Brashy
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  2. Fawzia A. Ibrahim
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  3. Saadia M. El-Ashry
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El-Brashy, A.M., Ibrahim, F.A. & El-Ashry, S.M. Colorimetric determination of some important hydrazine derivatives. Mikrochim Acta 105, 105–110 (1991). https://doi.org/10.1007/BF01243536

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  • DOI: https://doi.org/10.1007/BF01243536

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