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Output of endogenous monoamine oxidase inhibitor in rats: Effect of ethanol, tryptamine and tryptophan

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Summary

Contrary to prediction, loading rats with tryptamine, tryptophan or methanol failed to produce any rise in endogenous monoamine oxidase inhibitor output, whilst ethanol administration resulted in a significantly decreased excretion. These findings, which provide no support for the hypothesis that the inhibitor is aβ-carboline, may shed some light on the tranquillizing effect of ethanol in man.

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Author notes

  1. M. Sandler

    Present address: Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, London, UK

  2. Ines Armando

    Present address: Division de Endocrinologia, Hospital General de Niños “R.Gutierrez”, Gallo 1330, 1425, Buenos Aires, Argentina

Authors and Affiliations

  1. Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital, London, UK

    Ines Armando & Vivette Glover

  2. Department of Pharmacology, School of Pharmacy, University of London, Brunswick Square, London, UK

    Sandra E. File

Authors
  1. Ines Armando
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  2. Vivette Glover
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  3. M. Sandler
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  4. Sandra E. File
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Armando, I., Glover, V., Sandler, M. et al. Output of endogenous monoamine oxidase inhibitor in rats: Effect of ethanol, tryptamine and tryptophan. J. Neural Transmission 56, 85–90 (1983). https://doi.org/10.1007/BF01243376

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  • DOI: https://doi.org/10.1007/BF01243376

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