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The pathogenesis of poliomyelitis. Sites of multiplication of poliovirus in cynomolgus monkeys after alimentary infection

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Summary

The P 1549 (antigenic type 1) strain of poliovirus was administered by gavage to cynomolgus monkeys in order to obtain additional information on primary sites of multiplication of poliovirus. The first sites of virus multiplication were in tissues of the alimentary tract, principally in the oropharynx, and possibly in the ileum. During the early period in pathogenesis poliovirus was found also in lymph nodes collateral to these alimentary sites of multiplication. As early as 24 hours after detection of poliovirus in these tissues low concentrations of virus were detected in the blood; the concentration of virus in the blood rose gradually to reach maximal levels within 48 to 96 hours; thereafter, the concentration gradually fell until no further evidence of viremia was obtained by the 10 th day after infection. When the viremia was approaching, or had reached maximal levels poliovirus was distributed widely in all 46 tissues examined for its presence. Near the end of the period of viremia specific neutralizing antibodies were also found in the blood.

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References

  1. Bodian, D. andH. A. Howe: J. Exptl. Med.85, 231 (1947).

    Google Scholar 

  2. Bodian, D.: Science122, 105 (1955).

    Google Scholar 

  3. Bodian, D.: Am. J. Hyg.64, 181 (1956).

    Google Scholar 

  4. Faber, H. K.: The pathogenesis of poliomyelitis. Charles C. Thomas, Springfield, Illinois (1955).

    Google Scholar 

  5. Gebhardt, L. P. andJ. G. Bachtold: Proc. Soc. Exptl. Biol. Med.83, 807 (1953).

    Google Scholar 

  6. Reed, L. J. andH. Muench: Am. J. Hyg.27, 493 (1938).

    Google Scholar 

  7. Sabin, A. B.: Science123, 1151 (1956).

    Google Scholar 

  8. Shwartzman, G., S. M. Aronsen, C. Teodoru, M. Adler, andR. Jahiel: Ann N. Y. Acad. Sci.61, 869 (1955).

    Google Scholar 

  9. Wenner, H. A. andW. A. Tanner: Am. J. Med. Sci.216, 258 (1948).

    Google Scholar 

  10. Wenner, H. A., C. A. Miller, P. Kamitsuka, andJ. C. Wilson: Am. J. Hyg.59, 221 (1954).

    Google Scholar 

  11. Wenner, H. A. andP. Kamitsuka: Virology2, 83 (1956).

    Google Scholar 

  12. Wenner, H. A. andP. Kamitsuka: Virology3, 429 (1957).

    Google Scholar 

  13. Wenner, H. A., I. Archetti, andG. R. Dubes: Am. J. Hyg. (1959) in press.

  14. Toungner, J. S.: Proc. Soc. Exptl. Biol. Med.85, 202 (1954).

    Google Scholar 

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Author notes

  1. Italo Archetti

    Present address: Istituto Superiore di Sanità, Roma, Italy

Authors and Affiliations

  1. Hixon Memorial Laboratory, Department of Pediatrics, University of Kansas School of Medicine, Kansas City, Kansas

    Herbert A. Wenner, Paul Kamitsuka, Margaret Lenahan & Italo Archetti

Authors
  1. Herbert A. Wenner
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  2. Paul Kamitsuka
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  3. Margaret Lenahan
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  4. Italo Archetti
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Aided by a grant from The National Foundation.

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Wenner, H.A., Kamitsuka, P., Lenahan, M. et al. The pathogenesis of poliomyelitis. Sites of multiplication of poliovirus in cynomolgus monkeys after alimentary infection. Archiv f Virusforschung 9, 537–558 (1960). https://doi.org/10.1007/BF01242142

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  • DOI: https://doi.org/10.1007/BF01242142

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