Summary
Assays for African swine fever virus (ASFV) were conducted on 16 tissues of pigs serially killed at daily intervals following intranasal inoculation of ASFV. Virus was first detected at 1 day postinoculation in the tonsils, mandibular lymph nodes, and in circulating leukocytes in the blood. Once virus appeared in blood, it spread rapidly throughout the body and was detected at 3 days in all tissues examined. Highest viral titers were observed in tissues containing a large component of reticulo-endothelial cellular elements (108 50% hemadsorption units per gram). This correlates favorably with the observation that the significant lesions of African swine fever occur in such tissues.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cox, B. F., andW. R. Hess: Note on an African swine fever investigation in Nyasaland. Bull, epizoot. Dis. Afr.10, 439–440 (1962).
DeTray, D. E.: African swine fever in wart hogs (Phacochoerus aethiopicus). J. Amer. vet. med. Ass.130, 537–540 (1957).
DeTray, D. E.: African swine fever. Advanc. vet. Sci.8, 299–333 (1963).
Geiger, W.: Virusschweinepest und Afrikanische Virusseuche der Schweine. Thesis, Dr. Med. Vet., Tierärztliche Hochschule, Hannover (1937).
Hess, W. R., andD. E. DeTray: The use of leukocyte cultures for diagnosing African swine fever (ASF). Bull, epizoot. Dis. Afr.8, 317–328 (1960).
Heuschele, W. P., andL. Coggins: Isolation of African swine fever virus from a giant forest hog. Bull. epizoot. Dis. Afr.13, 255–256 (1965).
Kärber, G.: Beitrag zur kollektiven Behandlung pharmakologischer Reihenversuche. Arch. exp. Path. Pharmak.162, 480–487 (1931).
Korn, G.: Über die afrikanische Schweinepest und die Spezifität des Hämadsorptionstestes zu ihrer Diagnose. Mschr. Tierheilk.15, 225–232 (1963).
Malmquist, W. A., andD. Hay: Hemadsorption and cytopathic effect produced by African swine fever virus in swine borne marrow and buffy coat cultures. Amer. J. vet. Res.21, 104–108 (1960).
Malmquist, W. A.: Serologic and immunologic studies with African swine fever virus. Amer. J. vet. Res.24, 450–459 (1963).
Maurer, F. D., D. E. DeTray, J. Armstrong, K. L. Kuttler, B. C. Easterday, A. M. Webb, B. C. Swindle, W. Carpenter, andA. Chapel: Unpublished data from Foreign Disease Project 1001, Kenya (1954).
Maurer, F. D., R. A. Griesemer, andT. C. Jones: The pathology of African swine fever -a comparison with hog cholera. Amer. J. vet. Ees.9, 517–539 (1958).
Montgomery, R. E.: On a form of swine fever occurring in British East Africa (Kenya Colony). J. comp. Path.34, 159–191, 243–262 (1921).
Steyn, D. G.: East African virus disease in pigs. 18th Rept. Director Vet. Serv. Ind. Onderstepoort (South Africa)1, 99–109 (1932).
Walker, J.: East African swine fever. Thesis, University of Zürich, Switzerland, Bailliere, Tindall and Cox, London (1933).
Author information
Authors and Affiliations
Additional information
This paper was prepared under the terms of a Memorandum of Understanding between the East African Veterinary Research Organization and the U.S. Department of Agriculture, Agricultural Research Service, Animal Disease and Parasite Research Division.
Rights and permissions
About this article
Cite this article
Heuschele, W.P. Studies on the pathogenesis of african swine fever I. Quantitative studies on the sequential development of virus in pig tissues. Archiv f Virusforschung 21, 349–356 (1967). https://doi.org/10.1007/BF01241735
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01241735