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Variation in neurovirulence of NWS influenza virus after repeated passages in different tissue culture systems

II. Correlation between neurovirulence and some other genetic markers

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Summary

Several virus lines obtained by passaging the NWS virus strain in different tissue culture systems markedly differed in their neurotropic activity for mice. To investigate possible covariation between neurovirulence and other genetic markers, the following properties of the virus lines isolated were examined: thermoresistance of haemagglutinin, agglutination of red blood cells of different species, lethality for chick embryo, capability of growing in different tissue cultures and capability of reproduction at different temperatures. The results obtained failed to reveal any relationship between the loss of neurovirulence and changes in the markers tested.

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References

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Author notes

  1. Z. Janda

    Present address: Virus Department, Research Institute of Immunology, Prague, Czechoslovakia

Authors and Affiliations

  1. Virus Department, Research Institute of Immunology, Prague, Czechoslovakia

    V. Vonka

Authors
  1. Z. Janda
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  2. V. Vonka
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Janda, Z., Vonka, V. Variation in neurovirulence of NWS influenza virus after repeated passages in different tissue culture systems. Archiv f Virusforschung 24, 197–202 (1968). https://doi.org/10.1007/BF01241292

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  • DOI: https://doi.org/10.1007/BF01241292

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