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Biological activity of surfagon — A synthetic luliberin agonist

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Conclusions

  1. 1.

    Surfagon, an analog of luliberin, possesses high biological activity, surpassing the biological activity of luliberin by a factor of 10 in the test of stimulation of secretion of gonadotropins by the rat pituitary in vivo and in the test of induction of ovulation in rats.

  2. 2.

    Surfagon has a prolonged effect on the secretion of gonadotropins in vivo and in vitro.

  3. 3.

    The use of various doses of surfagon permits selective stimulation of secretion only of LH or of LH and FSH by the pituitary in rats.

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Authors and Affiliations

  1. All-Union Cardiologic Science Center, Academy of Medical Sciences of the USSR, Moscow

    O. G. Krivosheev, N. A. Nabatchikova, G. I. Pozdnyakova, E. A. Syutkin, V. A. Vinogradov, V. Ya. Chernykh, S. P. Veselova, T. R. Saks & F. E. Meertsuk

Authors
  1. O. G. Krivosheev
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  2. N. A. Nabatchikova
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  3. G. I. Pozdnyakova
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  4. E. A. Syutkin
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  5. V. A. Vinogradov
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  6. V. Ya. Chernykh
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  7. S. P. Veselova
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  8. T. R. Saks
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  9. F. E. Meertsuk
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Additional information

Translated from Problemy Éndokrinologii, Vol. 34, No. 6, pp. 62–66, November–December, 1988.

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Krivosheev, O.G., Nabatchikova, N.A., Pozdnyakova, G.I. et al. Biological activity of surfagon — A synthetic luliberin agonist. Neurosci Behav Physiol 19, 341–345 (1989). https://doi.org/10.1007/BF01236026

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  • DOI: https://doi.org/10.1007/BF01236026

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