Skip to main content
SpringerLink
Log in

Activity of ethylene oxide in the mouse sperm morphology test

  • Short Communication
  • Published:
Archives of Toxicology Aims and scope Submit manuscript

Abstract

Inhaled ethylene oxide induced an increased frequency of abnormal sperm cells in mice when the animals were treated at 200 and 400 ppm (6 h per day; 5 days) in three stages of cell development: spermatozoa, spermatid and preleptotene spermatogonial cells. These results suggest that sperm head morphology changes can be induced by interference of ethylene oxide with spermatogenesis, which, depending on the stage of the treated germ cells, may be correlated with the mutagenic potential of this chemical agent.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Chakravarti IM, Laha RG, Roy JR (1967) Handbook of methods of applied statistics. Vol. I, John Wiley, New York

    Google Scholar 

  • Goldberg RB, Geremia R, Bruce WR (1977) Histone synthesis and replacement during spermatogenesis in the mouse. Differentiation 7: 167–180

    PubMed  Google Scholar 

  • Oakberg EF (1956) Duration of spermatogenesis in the mouse and timing of stages of the cycle of the seminiferous epithelium. Am J Anat 99: 507–516

    PubMed  Google Scholar 

  • Oakberg EF (1957) Duration of spermatogenesis in the mouse. Nature (Lond) 180: 1137–1138

    Google Scholar 

  • Wyrobek AJ, Bruce WR (1975) Chemical induction of sperm abnormalities in mice. Proc Natl Acad Sci USA 72: 4425–4429

    PubMed  Google Scholar 

  • Wyrobek AJ, Bruce WR (1978) The induction of sperm-shape abnormalities in mice. In: Hollaender A, de Serres FJ (eds) Chemical mutagens — principles and methods for their detection, Vol. 5. Plenum, New York, pp 257–285

    Google Scholar 

  • Wyrobek AJ, Gordon LA, Burkhart JG, Francis MW, Kapp RW Jr, Letz G, Malling HV, Topham JC, Wharton DM (1983) An evaluation of the mouse sperm morphology test and other sperm tests in non-human mammals: A report of the US EPA Gene-Tox-Program, Mutat Res 115: 1–72

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratório de Toxicologia e Genética Toxicológica, Departamento de Patologia e Clínicas, Escola de Medicina Veterinária, Universidade Federal da Bahia, Av. Ademar de Barros, 500, Ondina, 40000, Salvador, Bahia, Brazil

    Lucia Regina Ribeiro

  2. Serviço de Genética, Instituto Butantan, São Paulo, Brazil

    Daisy Maria Fávero Salvadori & Willy Beçak

  3. Instituto de Matemática e Estatística da Universidade de São Paulo, São Paulo, Brazil

    Carlos Alberto Bragança Pereira

Authors
  1. Lucia Regina Ribeiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Daisy Maria Fávero Salvadori
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Carlos Alberto Bragança Pereira
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Willy Beçak
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ribeiro, L.R., Salvadori, D.M.F., Pereira, C.A.B. et al. Activity of ethylene oxide in the mouse sperm morphology test. Arch Toxicol 60, 331–333 (1987). https://doi.org/10.1007/BF01234675

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01234675

Key words

Search

Navigation