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Mutagenic activity of the feces of rats following oral administration of tartrazine

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Abstract

After oral administration of the azo dye tartrazine, bile and feces of treated rats were investigated for mutagenicity using the Ames test withSalmonella typhimurium strains TA 98 and TA 100 with and without metabolic activation. In the presence of S 9-mix fecal extracts developed a weak but reproducible dose-related response in strain TA 100. In bile no metabolites exerting mutagenic activity were found.

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Authors and Affiliations

  1. Institute of Biochemistry, Federal Research Centre for Nutrition, Engesserstr. 20, D-7500, Karlsruhe, Germany

    Ruth Münzner & Joachim Wever

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  1. Ruth Münzner
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  2. Joachim Wever
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Münzner, R., Wever, J. Mutagenic activity of the feces of rats following oral administration of tartrazine. Arch Toxicol 60, 328–330 (1987). https://doi.org/10.1007/BF01234674

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  • DOI: https://doi.org/10.1007/BF01234674

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