Abstract
The elevation of urinary trehalase activity in patients of itai-itai disease was examined. Urinary trehalase was correlated with tubular reabsorption of phosphorus (%TRP): the lower the trehelase activity, the worse was %TRP. Furthermore, this activity was inversely correlated with urinary glucose and urinary total protein. In itai-itai disease, the excretion of β2-microglobulin seems to be maximal, and urinary trehelase activity was low in the latter stages of the disease. It is inferred that itai-itai disease produces extremely severe tubular damage as well as glomerular dysfunction.
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Nakano, M., Aoshima, K., Katoh, T. et al. Elevation of urinary trehalase activity in patients of itai-itai disease. Arch Toxicol 60, 300–303 (1987). https://doi.org/10.1007/BF01234669
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DOI: https://doi.org/10.1007/BF01234669