Summary
Renal hyperfunction and hypertrophy are characteristic findings in the early diabetic state, both in diabetes mellitus and in experimental diabetes. A number of structure-function relationships and their likely mechanisms are discussed. The metabolically induced hypertrophy of glomerular capillaries possibly plays a central role. Its cause is not known, but recent results on its time-course emphasize the probable long-term consequences of the irreversibility of the accumulation of basement membrane material.
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Mogensen, C.E., Østerby, R. & Gundersen, H.J.G. Early functional and morphologic vascular renal consequences of the diabetic state. Diabetologia 17, 71–76 (1979). https://doi.org/10.1007/BF01222205
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DOI: https://doi.org/10.1007/BF01222205