Summary
Diabetic microangiopathy, particularly as seen in the renal glomerulus, is characterized by morphological and biochemical alterations of the capillary basement membrane. Observations from a number of disciplines have indicated that the microvascular disease is not a separately inherited entity but a true consequence or “complication” of insulin deficiency. An evaluation of the biochemical events which could be responsible for the basement membrane lesions of diabetes indicates that the hyperglycemia or plasma somatotropin elevation of this disease alone, or in combination, may play an important role.
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The Claude Bernard Lecture delivered before the European Association for the Study of Diabetes in Munich on September 6, 1975.
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Spiro, R.G. Search for a biochemical basis of diabetic microangiopathy. Diabetologia 12, 1–14 (1976). https://doi.org/10.1007/BF01221959
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DOI: https://doi.org/10.1007/BF01221959